From: Suicidality and divalproex sodium: analysis of controlled studies in multiple indications
Study | Treatment | Event, study day(s) | Age, years | Gender | Adverse event term(s) | Relevant history |
---|---|---|---|---|---|---|
Completed suicide: 0 | ||||||
Suicide attempts: 4 | ||||||
Mania maintenance | DVPX | 241 | 21 | Female | Overdose, suicide attempt | Benzodiazepine overdose after a family conflict. Family history of bipolar disorder; history of previous SA. |
Mania maintenance | DVPX | 313 | 43 | Female | Manic depressive reaction, overdose, suicide attempt | Benzodiazepine overdose. Family history of alcoholism, ADHD; previous SA approximately 12 months prior; SADS-C suicidal tendency score was 1 (not at all) on day 308. |
Mania maintenance | Placebo | 71 | 29 | Female | Overdose | Benzodiazepine + alcohol combination 'due to poor judgment'. Marital break-up and lost custody of children. Family history of anxiety, depression. |
Bipolar depressiona | Placebo | 19 | 18 | Male | Euphoria, abdominal pain, overdose | Amphetamine overdose. One SA in past year; mother died in past year; HAM-D rated as 0 (absent) and BPRS rated as 0 (not present) on day 15. |
Preparatory acts toward imminent suicidal behavior: 1 | ||||||
Mania maintenance | Placebo | 29 | 26 | Female | Depression | Severe depression and suicidal ideation 1 day post treatment. Family history of mood, eating, and drug abuse disorders; history of borderline personality disorder; five SA since 1983 (last approximately 1 year prior); SADS-C rated as 1 (not at all) on day -1, 2 (slight) on day 7 and 5 (severe) on day 29. |
Suicidal ideation: 15b | ||||||
Epilepsy, adjunctive CPS | DVPX | 19 | 21 | Female | Depression | Severe thoughts of suicide that resolved the next day. History of drug abuse (approximately 1 year recovered), violent during seizures, and decreased mental sharpness; CBZ. |
Acute mania | DVPX | 2 | 33 | Female | Depression | Moderate suicidal thoughts lasting 6 hours after a 'family event'. SADS-C rated as 0 (not at all) on day -1 and day 5. |
Mania maintenance | DVPX | 24 | 52 | Male | Depression | Moderate suicidal ideation. Family history of suicide, abuse, electroconvulsive therapy, and residing in mental institution; history of obesity, diabetes, cardiovascular disease; SADS-C rated as 2 (slight) on day 15 and 4 (moderate) on day 30. |
Mania maintenance | DVPX | 23 | 31 | Female | Depression | Severe depression, BDI indicated suicidal ideation. Family history of mood swings; SADS-C rated as 1 (not at all) on days -1 and 7, and 5 (severe) on day 24. |
Mania maintenance | DVPX | 196 | 22 | Male | Depression | Severe depression and suicidal ideation. SADS-C rated as 3 (mild) on day 1. |
Mania maintenance | DVPX | 1 | 28 | Male | Thinking abnormal thoughts | Moderate fleeting thoughts of wanting to hurt self (non-suicidal). SADS-C rated as 1 (not at all) on day -1, and 2 (slight) on day 18. |
Mania maintenance | DVPX | 44, 234 | 45 | Male | Depression | Two episodes of suicidal ideation (severe and mild, respectively). Family history of depression; SADS-C rated as 6 (extreme) on day 55 and 3 on day 218; paroxetine. |
Impulsive aggression | DVPX | 16 | 37 | Male | Depression | Severe hostility, depression and suicidal ideation, 'stress due to friend's death'. History of major depression, HIV positive (3 months), childhood physical abuse, possible PTSD; HAM-D rated as 1 (life not worth living) on day -22. |
Impulsive aggression | DVPX | 38 | 36 | Female | Depression | Moderate feelings of worthlessness and hopelessness, mild thoughts of suicide. History of intermittent explosive disorder, alcohol dependence, cluster B personality disorder-borderline; HAM-D was rated as 0 (absent) on days 28 and 48. |
Mania maintenance | Placebo | 54 | 31 | Male | Depression | Severe suicidal ideation and intent. Family history of depression; history of panic attacks; SADS-C rated as 3 (mild) on day 43 and 6 (extreme) on day 54; thyrosin, sertraline. |
Mania maintenance | Placebo | 188 | 45 | Female | Manic depressive reaction | Severe suicidal ideation. Family history of bipolar disorder, depression; SADS-C rated as 1 (not at all) on day 175 and 5 (severe) on day 188. |
Mania maintenance | Placebo | 116 | 41 | Female | Manic depressive reaction | Severe suicidal ideation and psychosis; SADS-C rated as 1 (not at all) on day 111 and 4 (moderate) on day 116. |
Mania maintenance | Placebo | 131 | 38 | Male | Depression | Mild and transient suicidal ideation after ethanol consumption. Family history of bipolar disorder; SADS-C rated as 2 (slight) on day 115. |
Mania maintenance | Placebo | 39 | 32 | Female | Psychotic depression | Severe depression and suicidal ideation. Family history of depression; SADS-C rated as 3 (mild) on day 28. |
Impulsive aggression | Placebo | 20 | 31 | Female | Depression | Mild suicidal ideation with no plans/means that resolved within 2 hours. History of major depression, physical abuse, witnessed domestic violence, borderline cluster B personality disorder; HAM-D rated as 0 (absent) on day -15 and 28. |
Epilepsy, monotherapy | Low-dose DVPX | 17 | 33 | Female | Depression | Moderate depression and thoughts of suicide. Marital and financial issues; history of anxiety, CBZ. |