From: Suicidality and divalproex sodium: analysis of controlled studies in multiple indications
Study | Population | Treatment group | OR (95% CI) | |
---|---|---|---|---|
 |  | DVPX, N = 1,327, n/N a | Placebo, N = 992, n/N a |  |
Placebo-controlled studies | ||||
Willmore et al. 1996 [30] | Epilepsy | 1/77 | 0/70 | 2.76 (0.11 to 68.98) |
Pope et al. 1991 [31] | Acute mania | 0/20 | 0/23 | - |
Bowden et al. 1994 [32] | Acute mania | 0/69 | 0/74 | - |
Bowden et al. 2000 [33] | Mania maintenance | 7/187 | 7/94 | 0.48 (0.16 to 1.42) |
Sachs et al. 2001 [34] | Bipolar depression | 0/23 | 1/22 | 0.31 (0.01 to 7.89) |
Hirschfeld et al. 2010 [35] | Acute mania | 1/146 | 0/78 | 1.62 (0.07 to 40.20) |
Tariot et al. 2001 [36] | Dementia | 0/87 | 0/85 | - |
Bowden et al. 2006 [37] | Acute mania | 0/192 | 0/185 | - |
Hollander et al. 2003 [38] | Impulsive aggression | 2/124 | 1/122 | 1.98 (0.18 to 22.16) |
Placebo-controlled studyb | Dementia | 0/78 | 0/43 | - |
Mathew et al. 1995 [39] | Migraine | 0/70 | 0/37 | - |
Klapper 1997 [40] | Migraine | 0/132 | 0/44 | - |
Freitag et al. 2002 [41] | Migraine | 0/122 | 0/115 | - |
Overall (placebo-controlled) | Â | 11/557c | 9/386c | 0.72 (0.29 to 1.84) |
High-dose DVPX vs low-dose DVPX | ||||
 |  | High-dose DVPX | Low-dose DVPX |  |
Beydoun et al. 1997 [42] | Epilepsy | 0/131 | 1/134 | 0.34 (0.01 to 8.38) |
Overall (all studies) | Â | 11/688c | 10/520c | 0.66 (0.27 to 1.64) |