Effect of cyproheptadine on combat related PTSD nightmares

  • Gholamhossien Ahmadzadeh1,

    Affiliated with

    • Ghorbanali Asadolahi1,

      Affiliated with

      • Gavad Mahmodi1 and

        Affiliated with

        • Arezoo Farhat1

          Affiliated with

          Annals of General Psychiatry20065(Suppl 1):S159

          DOI: 10.1186/1744-859X-5-S1-S159

          Published: 28 February 2006


          Recent studies have shown the role serotonergic system in post-traumatic stress disorder. Trazodone and Nefazodone (5H2 antagonist) amilorated PTSD nightmares but the receptors are mixed. This study promoted an open trial of cyporoheptadine for Iran versus Iraq combat related PTSD patients nightmares.

          Materials and methods

          25 patients studies in 8 week, before after trial of cyproheptadine, the participant were male and chronic PTSD patients with combat related nightmares.


          5 patients were excluded from the study because of side effects including dizziness and somnolence. 20 patients completed the study. Average nightmare severity decreased from 6.85 to 5.05 which was statistically signifcant (p < 0.01).


          Cyproheptadine may be effective in PTSD nightmare treatment.

          Authors’ Affiliations

          Behavioral Science Research Center, Khorshid Medical Center Esfahan


          1. Harsh HH: Cyorheptatine for recurrent nighmares. Am J Psy. 1986, 143: 1491-1492.View Article


          © The Author(s) 2006