Volume 5 Supplement 1

International Society on Brain and Behaviour: 2nd International Congress on Brain and Behaviour

Open Access

Effect of cyproheptadine on combat related PTSD nightmares

  • Gholamhossien Ahmadzadeh1,
  • Ghorbanali Asadolahi1,
  • Gavad Mahmodi1 and
  • Arezoo Farhat1
Annals of General Psychiatry20065(Suppl 1):S159

DOI: 10.1186/1744-859X-5-S1-S159

Published: 28 February 2006

Background

Recent studies have shown the role serotonergic system in post-traumatic stress disorder. Trazodone and Nefazodone (5H2 antagonist) amilorated PTSD nightmares but the receptors are mixed. This study promoted an open trial of cyporoheptadine for Iran versus Iraq combat related PTSD patients nightmares.

Materials and methods

25 patients studies in 8 week, before after trial of cyproheptadine, the participant were male and chronic PTSD patients with combat related nightmares.

Results

5 patients were excluded from the study because of side effects including dizziness and somnolence. 20 patients completed the study. Average nightmare severity decreased from 6.85 to 5.05 which was statistically signifcant (p < 0.01).

Discussion

Cyproheptadine may be effective in PTSD nightmare treatment.

Authors’ Affiliations

(1)
Behavioral Science Research Center, Khorshid Medical Center Esfahan

References

  1. Harsh HH: Cyorheptatine for recurrent nighmares. Am J Psy. 1986, 143: 1491-1492.View ArticleGoogle Scholar

Copyright

© The Author(s) 2006

Advertisement