Volume 5 Supplement 1

International Society on Brain and Behaviour: 2nd International Congress on Brain and Behaviour

Open Access

The comparison between prazosin versus clonidine effects on combat related P.T.S.D nightmares

  • Seyed Mousavi1,
  • Majid Barati1,
  • Hamid Afshar1 and
  • Nasrollah Bashardoust2
Annals of General Psychiatry20065(Suppl 1):S190

DOI: 10.1186/1744-859X-5-S1-S190

Published: 28 February 2006

Background

P.T.S.D is a psychiatric (anxiety) disorder that may develops after a catastrophic stress. One of it's symptoms is nightmares that usually is severe and impaire sleep. Some studies show increased activity of adrenergic system in this disorder.

Also, some drugs such as clonidine, guanfacine and prazosin that decrease the activity of this system, decrease symptoms of PTSD, such as nightmares.

At this study we compared the effects of clonidine versus prazosin on nightmares of these partients.

Materials and methods

On a dobule blinded clinical trial we studied two groups of inpatient PTSD by using clonidine or prazosin in each group for 8 weeks.

Then we rate the frequency, deepness and serverity of the nightmares by CAPS.

All of the patients were male, married and chronic form of disorder.

The data were analysed by X2, t-pared and t-student.

Results

In both groups the average of nightmares severity reduced, and they were statistically significant (p < 0.001), but the difference between two groups were not statistically significant (p > 0.05).

Discussion

Prazosin and clonidine may be effective for treatment of nightmares of PTSD patient's but there are not significant differences between them.

Authors’ Affiliations

(1)
Behavioral Sciences Research Center, Isfahan University of Medical Sciences
(2)
Isfahan University of Medical Sciences, Facutly of Health

References

  1. Wolf J, Ericson DJ, Sharkansky E: Course and predictors of posttraumatic stress disorder among gulf war weterans: a prospective analysis. Yearbook of Psychiatry and Applied Mental Health. Edited by: Talbot JA. 2001, USA: Mosby, 224-Google Scholar
  2. Charong DS, Nagy LM, Daglas J: Serotonergic system. Synopsis of Psychiatry. Edited by: Fogal B. 2000, Williams and Wilkins, 280-283.Google Scholar
  3. Jackobs RS, Schnurr PP, Friedman MJ, Pack R, Brophy M, Fuller D: Post traumatic stress disorderand sleep difficulty. Am J Psychiatry. 2000, 157: 1525-10.1176/appi.ajp.157.9.1525.View ArticleGoogle Scholar
  4. Riynsers RJP, Lamar DM, Diugan HV: Cyproheptadine for PTSD nightmares. Am J. 2000, 157: 524-525.Google Scholar

Copyright

© The Author(s) 2006

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