Table 4 Effect of bupropion HCl 120 mg/kg intraperitoneal infusion times on the mean ± SD duration of bupropion HCl-induced convulsions in mice
Group* | Intraperitoneal (IP) infusion time (min) | Mean ± SD duration of convulsions | ||
|---|---|---|---|---|
| Â | Â | Short (0 to 10 s) | Medium (11 to 30 s) | Long (= 31 s) |
1 | 0 (bolus) | 11.2 ± 15.6 | 2.6 ± 3.9 | 1.6 ± 4.4 |
2 | 15 | 19.9 ± 31.4 | 4.8 ± 8.0 | 2.3 ± 3.3 |
3 | 30 | 12.2 ± 15.7 | 2.5 ± 4.1 | 1.4 ± 4.1 |
4 | 60 | 12.0 ± 17.7 | 3.8 ± 7.1 | 1.0 ± 1.7 |
5 | 90 | 0 | 0 | 0 |
6 | 120 | 3.1 ± 9.5 | 0.2 ± 0.6 | 0.1 ± 0.3 |
7 | 240 | 0 | 0 | 0 |