Table 5 Effect of bupropion HCl 120 mg/kg intraperitoneal infusion times on the mean ± SD intensity of bupropion HCl-induced convulsions in mice
Group* | Intraperitoneal (IP) infusion time (min) | Mean ± SD intensity of convulsions | ||
|---|---|---|---|---|
| Â | Â | Mild | Moderate | Severe |
1 | 0 (bolus) | 10.0 ± 12.9 | 5.5 ± 10.4 | 0 |
2 | 15 | 14.2 ± 17.4 | 7.1 ± 10.9 | 5.9 ± 13.1 |
3 | 30 | 9.2 ± 11.7 | 4.1 ± 6.4 | 2.8 ± 8.9 |
4 | 60 | 10.2 ± 16.4 | 4.6 ± 7.0 | 2.2 ± 4.8 |
5 | 90 | 0 | 0 | 0 |
6 | 120 | 2.8 ± 8.5 | 0.5 ± 1.6 | 0.1 ± 0.3 |
7 | 240 | 0 | 0 | 0 |