Volume 7 Supplement 1

International Society on Brain and Behaviour: 3rd International Congress on Brain and Behaviour

Open Access

Application of Clozapine to aggressive patients

  • Ruslan Tonev1,
  • Tony Donchev2 and
  • Vladimir Nakov3
Annals of General Psychiatry20087(Suppl 1):S150

DOI: 10.1186/1744-859X-7-S1-S150

Published: 17 April 2008


Definitions. Aggression types. Therapeutic methods for coping aggression.

Assessment of the drug effect in aggressive patients with different nosological belonging.

Materials and methods

Three groups of patients /aggressive patients with schizophrenia, potentially aggressive patients with schizophrenia and aggressive patients with personal disorder/ age 18-60, without any significant somatic diseases, with diagnosis paranoid schizophrenia and personal disorder, are studied. Clozapine is applied in variable doses. A battery of psychological tests for aggression assessment is used. Personality evaluation was made by IPDE for patients with personality disorders. Diagnostic procedures included ICD-10 criteria.


There is a considerable reduction of aggressive behaviour by fast dosage titration of Clozapine. The side effects affect significantly the patients' compliance


It is observed a good compliance in low Clozapine dosage (under 100 mg.). We consider that the better compliance is also linked with a regular blood count providing therapeutic contacts with patients.

Authors’ Affiliations

Prison Kajluka
Military Medical Academy, Department of Psychiatry–Sofia
Diagnostic Consultative Centre XXVIII-Sofia


© Tonev et al.; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.