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Involvement of GABA-B receptors of the dorsal hippocampus in the inhibition of morphine-induced amnesia by morphine sensitization
Annals of General Psychiatry volume 7, Article number: S207 (2008)
Background
Our previous studies show that pre-training administration of morphine induces amnesia [1] and this effect was significantly reduced in morphine-sensitized mice [2]. In the present study the role of GABA-B receptors of the dorsal hippocampus in the inhibition of morphine-induced amnesia by morphine sensitization were investigated in mice.
Materials and methods
A single-trial step-down passive avoidance task was used for the assessment of memory retention in adult male NMRI mice. Animals were bilaterally cannulated in the CA1 regions by stereotaxic instrument, and were allowed to recover 1-week before behavioral testing.
Results
Morphine-induced amnesia was reversed in morphine-sensitized mice which had previously received once daily injections of morphine for 3 days. The inhibition of morphine-induced amnesia in animals that had previously received the 3-days morphine treatment was significantly decreased by once daily injections of the different doses of GABA-B receptor agonist, baclofen prior to s.c. injections of morphine. Amnesia induced by pre-training morphine had no significant change in mice which had previously received once daily injections of CGP35348 plus an ineffective dose of morphine for 3 days.
Conclusions
The present results indicate that GABA-B receptors of the dorsal hippocampus may play an important role in the inhibition of morphine-induced amnesia by morphine sensitization.
References
Zarrindast MR, Jafari-Sabet M, Rezayat M, Djahanguiri B, Rezayof A: Involvement of NMDA receptors in morphine state-dependent learning. Intern J Neuroscience. 2006, 116: 1-13. 10.1080/00207450690962208.
Zarrindast MR, Rezayof A: Morphine state-dependent learning: sensitization and interactions with dopamine receptors. Eur J Pharmacol. 2004, 497: 197-204. 10.1016/j.ejphar.2004.06.041.
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Zarrindast, MR., Hoghooghi, V. & Rezayof, A. Involvement of GABA-B receptors of the dorsal hippocampus in the inhibition of morphine-induced amnesia by morphine sensitization. Ann Gen Psychiatry 7 (Suppl 1), S207 (2008). https://doi.org/10.1186/1744-859X-7-S1-S207
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DOI: https://doi.org/10.1186/1744-859X-7-S1-S207