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Volume 7 Supplement 1

International Society on Brain and Behaviour: 3rd International Congress on Brain and Behaviour

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The effects of cannabinergic agents in the central amygdala of rats in the elevated plus-maze test of anxiety

Annals of General Psychiatry volume 7, Article number: S331 (2008) Cite this article

Background

Reports indicate that cannabinergic agents can change anxiety-related behaviours in both animals and humans. The amygdala is an important brain site in the modulation of fear or anxiety.

Materials and methods

In the present study, we investigated the effects of intracentral amygdala microinjection of cannabinergic agents on anxiety-related behaviours in rats, using the elevated plus-maze test of anxiety. Intracentral amygdala administration of ACPA a cannabinergic potent agonist (0.125, 1.25,5 ng/0.5 μl bilateral) increased %open arm time and % open arm entries, but not locomotor activity, showing an anxilytic response. Intracentral amygdala microinjection of AM251 a potent CB1 antagonist (2.5, 25, 100 ng/0.5 μl bilateral) did not change anxiety-related parameters in our experiments.

Results

The results suggest that cannabinergic agonists may reduce anxiety via CB1 receptors in the rat central amygdala.

Conclusions

Couse that CB1 antagonist didn't show any effect on anxiety we think that CB1 isn't the main receptor in central amygdala.

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Authors and Affiliations

  1. Depatment of pharmacology & toxicology, Ahvaz Jondi shapour University of Medical Sciences, Ahvaz, Khoozestan, Iran

    Shadi Sarahroodi & Ardeshir Arzi

  2. Department of pharmacology, Tehran University of Medical Sciences, Tehran, Iran

    Mohamma Reza Zarrindast

  3. Departement of Biology, Azad Islamic University, Tehran, Iran

    Saba Taheri Shalmani & Sara Mahboubi

Authors
  1. Shadi Sarahroodi
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  2. Mohamma Reza Zarrindast
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  3. Ardeshir Arzi
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  4. Saba Taheri Shalmani
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  5. Sara Mahboubi
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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sarahroodi, S., Zarrindast, M.R., Arzi, A. et al. The effects of cannabinergic agents in the central amygdala of rats in the elevated plus-maze test of anxiety. Ann Gen Psychiatry 7 (Suppl 1), S331 (2008). https://doi.org/10.1186/1744-859X-7-S1-S331

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  • DOI: https://doi.org/10.1186/1744-859X-7-S1-S331

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Annals of General Psychiatry

ISSN: 1744-859X