Volume 7 Supplement 1

International Society on Brain and Behaviour: 3rd International Congress on Brain and Behaviour

Open Access

Modulation of the acetylcholine-catecholamine balance in the cognitive processes and its correlations with the oxidative stress

  • Alin Ciobica1,
  • Manuela Padurariu2,
  • Lucian Hritcu1 and
  • Vlad Artenie1
Annals of General Psychiatry20087(Suppl 1):S348

DOI: 10.1186/1744-859X-7-S1-S348

Published: 17 April 2008

Background

Impairments of cognitive performance have been observed our previous studies in normal rats with muscarinic acethylcholine receptors (mAchRS), beta-adrenergic receptors (β AR) and D2-dopamine receptors (D2R) blockade, suggesting that these receptors have a facilitator role in learning and memory processes. Learning and memory processes are coordinated with different brain regions [1]. Since the oxidative damage may play a role in the aging process [2], including the associated decline, age-related impairment in spatial learning and memory may be alleviated by antioxidant treatment [3].

Materials and methods

Learning and memory tasks : Y-maze task; Step-through passive avoidance task.

Biochemical estimation : Determination of superoxid dismutaze (SOD), Determination of glutathione peroxidase (GPX), Determination of malondialdehyde (MDA).

Results

We observed that the levels of superoxide dismutase (SOD) and glutathione peroxidase (GPX) decrease in rats with mAchRS, D2R and β AR blockade by means of scopolamine (0.75 mg/kg b.w., i.p.), spiperone (0.4 mg/kg b.w.,i.p.) and propranolol (12 mg/kg b.w., i.p.), respectively, and the level of malondialdehyde (MDA) increase in the same rats, compared with saline-treated rats.

Conclusions

Muscarinic cholinergic and dopaminergic systems have a facilitating effect on mechanism that operates during the storage of information as memory engrams. We demonstrated that the increased oxidative stress is followed by cognition impairment in rats. Our findings support the hypothesis that oxidative stress plays a crucial role in brain dysfunction, contributing to the learning and memory deficits in rats.

Declarations

Acknowledgements

This research was supported by the National Council of Scientific Research and University Education (Grant TD CNCSIS no. 464), Romania.

Authors’ Affiliations

(1)
Alexandru Ioan Cuza, University, Dept. of Molecular and Experimental Biology
(2)
Gr. T. Popa, University of Medicine and Pharmacy

References

  1. Ekstrom AD, Bookheimer SY: Spatial and temporal episodic memory retrieval recruit dissociable functional networks in the human brain. Learn Mem. 2007, 14: 645-654. 10.1101/lm.575107.PubMed CentralView ArticlePubMedGoogle Scholar
  2. Flora SJ: Role of free radicals and antioxidants in health and disease. Cell Mol Biol. 2007, 53: 1-2.PubMedGoogle Scholar
  3. Barichello T, Machado RA, Constantino Valvassori: Antioxidant treatment prevented late memory impairment. Crit Care Med. 2007, 35: 2186-2190. 10.1097/01.CCM.0000281452.60683.96.View ArticlePubMedGoogle Scholar

Copyright

© Ciobica et al.; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

Advertisement