Table 3 Adverse drug event reports linking isotretinoin and psychiatric side effects
Reference | Year | No. of patients | Psychiatric adverse effect |
|---|---|---|---|
US Food and Drug Administration [25] | 1982 to 2004 | 4,992 | Various psychiatric side effects: 192 suicide attempts |
Canada [26] | 1983 to 2003 | 56 | Depression |
UK [27] | 1982 to 2006 | 463 | Suspected psychiatric events: 25 completed suicides |
Australia [28] | 1985 to 1988 | 12 | Depression: Suicide attempts (2) |