Treatment of psychotic symptoms in bipolar disorder with aripiprazole monotherapy: a meta-analysis

Table 3 Dropout in aripiprazole randomised controlled trials (RCTs) for acute mania; data concern numbers of patients while the last row concerns rates

Trial	Aripiprazole								Placebo				Comparator
	3 weeks				12 weeks				3 weeks				3 weeks				12 weeks
	Total	LE	AE	CW	Total	LE	AE	CW	Total	LE	AE	CW	Total	LE	AE	CW	Total	LE	AE	CW
CN138-009	76	23	11	25					104	53	13	38
CN138-074	58	12	12	34					64	28	10	26
CN138-135	82	9	23	15	113	12	31	70	87	36	13	10	82	26	21	5	106	26	28	52
CN138-162	41	9	14	18	72	13	24	35	44	14	16	14	44	10	8	26	70	11	18	41
CN138-007
CN138008	41	-	17	-	86	30	32	24					77	-	53	-	122	10	84	28
All RCTs
Dropout (%)	40.38	9.35	10.43	16.23	56.81	11.53	18.24	27.04	52.46	22.98	9.12	15.44	42.83	11.39	17.30	9.81	62.87	9.92	27.43	25.53
Only RCTs with PANSS data
Dropout (%)	36.22	6.79	10.77	15.16	56.81	11.53	18.24	27.04	43.62	17.45	8.72	11.19	42.83	11.39	17.30	9.81	62.87	9.92	27.43	25.53

Dash indicates missing data.
AE = adverse events; CW = consent withdrawal or other; LE = lack of efficacy; PANSS = Positive and Negative Syndrome Scale.

ISSN: 1744-859X