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Table 6 Side effects profile of aripiprazole in comparison to placebo (difference percentage).

From: Treatment of psychotic symptoms in bipolar disorder with aripiprazole monotherapy: a meta-analysis

Trial

Target

Overall side effects

Anxiety

Agitation

Acathisia

Constipation

Headache

Hyperprolactinaemia

Insomnia

Nausea

Sedation

CN138-009

Mania

 

8

1

9

7

5

-6

6

13

15

CN138-074

Mania

6

2

0.4

13.1

6.5

0.2

-7

 

5.5

9.4

CN138-135

Mania

   

8

4.3

0.8

  

9.3

6.8

CN138-162

Mania

0.1

11.4

 

6.8

 

1.8

 

2.1

 

5.4

CN138008

Mania

   

11.4

 

10.9

 

13.7

  

CN138-096

Depression

11

2.9

4.7

22.7

-1.5

-1.1

 

11.5

9.8

1.3

CN138-146

Depression

6

6.5

9.3

18.6

1.6

-2.3

 

7.7

6.6

1.1

CN138-010

Maintenance

6

-14.5

-10.8

6.6

 

7.8

 

-19.3

4.3

-7.2

CN138-134

Mania

8.3

  

13.2

    

5.2

 
  1. Negative results suggest the effect in question was more frequent in the placebo group.