Table 1 Characteristics of the patients in the daily treatment group and twice weekly treatment group
Daily treatment group | Twice weekly treatment group | Significance | |
|---|---|---|---|
Mean (SD) years of age | 10.5 (3.1) | 10.8 (2.0) | t = .3, df = 34, P = 0.72 |
Gender | |||
Boys | 16 (80 %) | 14 (87.5 %) | P = 0.67 |
Girls | 4 (20 %) | 2 (12.5 %) | |
Comorbid psychiatric disorder | |||
ADHD | 6 (37.5 %) | 5 (41.7 %) | X2 = 0.05, df = 1, P = 0.8 |
Oppositional defiant disorder | 7 (43.8 %) | 7 (58.3 %) | X2 = 0.5, df = 1, P = 0.4 |
Separation anxiety disorder | 0 | 2 (16.7 %) | – |
Obsessive compulsive disorder | 1 (6.2 %) | 0 | – |
Con-current medications (n) | |||
Carbamazepine | 1 | – | – |
Ritalin (10 mg/day) | 1 | – | – |
Imipramine (10 mg/day) + haloperidole (0.5 mg/day) | – | 1 | – |
Mean dosage of aripiprazole | |||
First 2 weeks | 3.5 | 3.8 | – |
Second 2 weeks | 3.8 | 4.6 | – |
Second month | 4.0 | 4.5 | – |
Motor and vocal tics score | |||
Baseline | 33.6 (18.2) | 31.3 (7.6) | t = .4, df = 34, P = 0.6 |
Week 2 | 15.1 (10.8) | 12.8 (9.1) | t = 0.6, df = 32, P = 0.52 |
Week 4 | 11.0 (9.7) | 12.8 (10.9) | t = 0.5, df = 31, P = 0.6 |
Week 8 | 6.6 (5.9) | 9.7 (11.2) | t = 1.03, df = 32, P = 0.3 |
Mean (SD) decline of total Yale motor and vocal tic severity scale score during trial | 22.8 (18.5) | 22.0 (11.6) | t = 1.07, df = 32, P = 0.2 |
Response rate with more than 35 % decline in total Yale motor and vocal tic severity scale score | 19 (100.0 %) | 11 (73.3 %) | P < 0.02 |
Response rate with more than 50 % decline in total Yale motor and vocal tic severity scale score | 17 (89.5 %) | 11 (73.3 %) | P = 0.2 |
Total Yale global tic severity scale score (motor tics + vocal tics + impairments) | |||
Baseline | 89.6 (39.2) | 93.8 (29.3) | t = 0.3, df = 34, P = 0.72 |
Week 2 | 39.5 (33.33) | 37.8 (31.3) | t = 0.1, df = 32, P = 0.8 |
Week 4 | 27.1 (31.9) | 39.2 (36.7) | t = 1.0, df = 31, P = 0.31 |
Week 8 | 15.3 (17.2) | 29.7 (37.1) | t = 1.4, df = 32, P = 0.14 |
Mean (SD) decline of total Yale global tic severity scale score during trial (motor tics + vocal tics + impairments) | 76 (37.9) | 64.6 (44.2) | t = 0.8, df = 32, P = 0.4 |
Response rate with more than 35 % decline in total Yale global tic severity scale score (motor tics + vocal tics + impairments) | 19 (100.0 %) | 11 (73.3 %) | P < 0.02 |
Response rate with more than 50 % decline in total Yale global tic severity scale score (motor tics + vocal tics + impairments) | 17 (89.5 %) | 11 (73.3 %) | P = 0.3 |