Impact of adverse reactions to first-generation antipsychotics on treatment adherence in outpatients with schizophrenia: a cross-sectional study

Table 2 Adverse drug reactions as predictors of non-adherence at multivariable level

Variables	Adherent		AOR (95% CI)	p value
	Yes	No
	n (%)	n (%)
Extrapyramidal ADRs
Yes	101 (64.7)	85 (98.8)	44.69 (5.98, 334.30)	0.000^a
No	55 (35.3)	1 (1.2)	Ref
Psychic ADRs
Yes	136 (87.2)	85 (98.8)	14.90 (1.90, 116.86)	0.010^a
No	20 (12.8)	1 (1.2)	Ref
Allergic ADRs
Yes	59 (37.8)	48 (55.8)	1.70 (0.92, 3.14)	0.090
No	97 (62.2)	38 (44.2)	Ref
Anticholinergic ADRs
Yes	109 (69.9)	68 (79.1)	1.29 (0.65, 2.52)	0.467
No	47 (30.1)	18 (20.9)	Ref
Hormonal ADRs
Yes	76 (48.7)	65 (75.6)	2.60 (1.41, 4.80)	0.002^a
No	80 (51.3)	21 (24.4)	Ref
Autonomic ADRs
Yes	111(71.2)	78 (90.7)	3.23 (1.37, 7.57)	0.007^a
No	45 (28.8)	8 (9.3)	Ref
Miscellaneous ADRs
Yes	94 (60.3)	67 (77.9)	2.16 (1.13, 4.12)	0.020^a
No	62 (39.7)	19 (22.1)	Ref

Variables	Adherent		AOR (95% CI)	p value
	Yes	No
	Md (IQR)	Md (IQR)
Total ADRs score	20.0 (20.75)	38.0 (26.25)	1.06 (1.04, 1.09)	0.000^a

Educational level, dose, smoking and red herrings were controlled in the relationship of total ADRs score and each LUNSERS subscale with non-adherence
ADR Adverse drug reaction, AOR adjusted odds ratio, CI confidence interval, n number of participants, Md median, IQR inter quartile range;
^aSignificant

ISSN: 1744-859X