Table 1 Description of included studies
Study | Year | Comparison | UA, Mean ± SD (μmol/L) | Sample size | NOS |
|---|---|---|---|---|---|
Wan JL 1 | 2022 | Bipolar Disorder/Healthy Control | 284.83 ± 103.35/282.55 ± 57.8 | 60/60 | 8 |
Lin XB | 2022 | Bipolar Disorder/Healthy Control/BD manic episode/BD depressed episode | 358.42 ± 78.96/281.96 ± 72.57/365.84 ± 72.57/349.35 ± 68.74 | 84/84/51/33 | 8 |
Wan JL 2 | 2022 | BD manic episode/BD depressed episode | 315.67 ± 92.57/284.83 ± 103.35 | 55/54 | 7 |
Wu Y | 2022 | Bipolar Disorder/Healthy Control/BD manic episode/BD depressed episode | 380.23 ± 105.28/311.65 ± 82.12/395.09 ± 105.51/338.42 ± 93.6 | 183/135/135/48 | 6 |
Li SY | 2021 | Bipolar Disorder/Healthy Control | 463.85 ± 41.48/285.47 ± 53.14 | 48/48 | 8 |
Li ZL | 2021 | Bipolar Disorder/Healthy Control/BD manic episode/BD depressed episode/BD mixed episode | 378.69 ± 76.52/305.76 ± 56.94/378.94 ± 67.89/380.72 ± 68.51/373.25 ± 63.84 | 132/132/66/39/27 | 7 |
Xu RH | 2020 | Bipolar Disorder/Healthy Control/Schizophrenia/BD manic episode/BD depressed episode | 350.28 ± 101.26/280.79 ± 70.64/318.79 ± 84.56/368.55 ± 103.59/321.39 ± 95.64 | 160/120/120/98/62 | 8 |
Dong R | 2020 | Bipolar Disorder/Healthy Control/Schizophrenia | 357.26 ± 80.1/272.81 ± 70.82/318.62 ± 70.37 | 133/133/133 | 6 |
Bai XY | 2019 | Bipolar Disorder/Healthy Control/BD manic episode/BD depressed episode/BD mixed episode | 340 ± 77/268 ± 64/350 ± 87/320 ± 66/355 ± 75 | 96/144/30/36/30 | 7 |
Xing ZQ | 2019 | Bipolar Disorder/Healthy Control | 461.59 ± 60.4/283.13 ± 56.73 | 104/72 | 7 |
Zhang HW | 2019 | Bipolar Disorder/Healthy Control/BD manic episode/BD depressed episode | 358.27 ± 79.41/282.53 ± 73.56/364.74 ± 77.28/349.41 ± 69.87 | 98/50/60/38 | 6 |
Yuan ZW | 2019 | BD manic episode/BD depressed episode/BD mixed episode | 357.75 ± 89.83/331.31 ± 72.4/351.89 ± 50.44 | 90/67/23 | 7 |
Zhang LG | 2018 | Bipolar Disorder/Healthy Control | 371.17 ± 104.63/301.1 ± 78.4 | 105/105 | 7 |
Zhang XM | 2018 | Bipolar Disorder/Healthy Control/Depression/BD manic episode/BD depressed episode/BD mixed episode | 353.46 ± 114.57/296.55 ± 84.03/292.7 ± 85.12/364.02 ± 103.03/330.18 ± 129.83/352.4 ± 138.1 | 183/130/88/116/52/15 | 7 |
Li B | 2018 | Bipolar Disorder/Healthy Control/BD manic episode/BD depressed episode/BD mixed episode | 378.85 ± 76.72/306.95 ± 56.93/375.09 ± 67.71/381.23 ± 68.54/369.37 ± 63.63 | 92/92/36/45/11 | 6 |
Wang Y | 2017 | Bipolar Disorder/Healthy Control/Schizophrenia/BD manic episode/BD depressed episode | 349.44 ± 106.21/281.84 ± 70.93/318.81 ± 85.58/365.54 ± 103.11/321.45 ± 107.68 | 322/322/77/197/125 | 7 |
Xu YX | 2016 | Bipolar Disorder/Healthy Control/BD manic episode/BD depressed episode | 389.43 ± 83.22/282.55 ± 70.24/391.55 ± 84.88/384.95 ± 80.61 | 109/74/74/35 | 7 |
Chen HM | 2016 | Bipolar Disorder/Healthy Control/Schizophrenia/BD manic episode/BD depressed episode | 349.34 ± 107.21/280.94 ± 71.9/319.71 ± 84.48/366.45 ± 104.01322.45 ± 107.69 | 126/126/69/77/49 | 8 |
Chen WX | 2021 | Bipolar Disorder/Healthy Control/Schizophrenia/BD manic episode/BD depressed episode | 346.76 ± 100.94/276.9 ± 50.77/310 ± 76.54/367.9 ± 100.56/319.86 ± 95.28 | 80/80/50/38/42 | 5 |
Deng SS | 2019 | Bipolar Disorder/Healthy Control | 398.09 ± 98.5/354.9 ± 84.87 | 63/100 | 5 |
Li Y | 2017 | Bipolar Disorder/Healthy Control | 369.12 ± 107.49/301.32 ± 76.02 | 88/88 | 6 |
Du HM | 2022 | Bipolar Disorder/Healthy Control/Depression | 349.61 ± 102.02/331.19 ± 104.03/308.7 ± 91.53 | 86/66/73 | 7 |
Li SY | 2022 | Bipolar Disorder/Healthy Control | 377.87 ± 102.15/356.04 ± 100.22 | 182/182 | 7 |
Zhu YC | 2022 | Bipolar Disorder/Depression | 351.4 ± 106.87/311.9 ± 93.58 | 955/1188 | 6 |
Lu Z | 2021 | Bipolar Disorder/Healthy Control/Depression/BD manic episode/BD depressed episode | 354.02 ± 88.75/296.27 ± 68.77/282.13 ± 77.98/367.84 ± 92.92/337.93 ± 81.54 | 119/180/95/64/55 | 8 |
Chen JX | 2018 | Bipolar Disorder/Healthy Control | 348.5 ± 91.8/300.2 ± 76.6 | 318/160 | 8 |
Yang XD | 2018 | Bipolar Disorder/Healthy Control | 354.64 ± 90.37/332.96 ± 88.7 | 141/151 | 8 |
Wen SL | 2012 | Bipolar Disorder/Healthy Control/Depression/Schizophrenia | 323.04 ± 108.7/315.76 ± 87.5/271.97 ± 77.5/341.03 ± 106.84 | 126/42/124/336 | 7 |