Fig. 2
From: Role of trazodone in treatment of major depressive disorder: an update
Trazodone affinities at neurotransmitter receptors and transporters. The most potent action is antagonism at 5-HT2A receptors. 5-HT2A and 5-HT2C, subtypes of 5-hydroxytryptamine receptors; α1 and α2, subtypes of alpha adrenergic receptors; H1, histamine 1 receptor; SERT, serotonin reuptake transporter; D2, dopamine 2 receptor; DAT, dopamine transporter; M1, muscarinic 1 cholinergic receptor; NET, norepinephrine transporter. (From Stahl [22]