Table 7 Relationships between different DNMT1 and DNMT3B genotypes and PANSS scores in schizophrenia group
SNP | rs2114724 | rs2228611 | rs1569686 | rs2424908 | rs2424932 | rs6119954 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Genotype (n) | CC (57) | CT (57) | TT (20) | CC (57) | CT (57) | TT (20) | GG (3) | GT (9) | TT (122) | CC (23) | CT (59) | TT (52) | AG (12) | GG (122) | AA (8) | AG (56) | GG (70) | |
P1 (delusions) | X2 (P) | 6.201 (0.045) | 6.201 (0.045) | 3.054 (0.217) | 2.183 (0.336) | 1.078 (0.281) | 1.664 (0.435) | |||||||||||
P2 (conceptual disorganization) | X2 (P) | 0.715 (0.699) | 0.715 (0.699) | 0.158 (0.924) | 0.542 (0.763) | 0.044 (0.965) | 1.555 (0.460) | |||||||||||
P3 (hallucinatory behavior) | X2 (P) | 7.851 (0.020) | 7.851 (0.020) | 5.685 (0.058) | 0.052 (0.975) | 1.878 (0.060) | 0.020 (0.990) | |||||||||||
P4 (excitement) | X2 (P) | 0.300 (0.861) | 0.300 (0.861) | 0.888 (0.641) | 4.028 (0.133) | 0.894 (0.371) | 3.662 (0.160) | |||||||||||
P5 (grandiosity) | X2 (P) | 1.264 (0.532) | 1.264 (0.532) | 0.918 (0.632) | 0.219 (0.896) | 0.315 (0.753) | 5.937 (0.051) | |||||||||||
P6 (suspiciousness/persecution) | X2 (P) | 10.387 (0.006) | 10.387 (0.006) | 2.659 (0.265) | 0.209 (0.901) | 1.292 (0.196) | 0.431 (0.806) | |||||||||||
P7 (hostility) | X2 (P) | 1.954 (0.376) | 1.954 (0.376) | 2.142 (0.343) | 1.062 (0.588) | 0.203 (0.839) | 1.474 (0.478) | |||||||||||
Total of positive symptoms | X2 (P) | 8.471 (0.014) | 8.471 (0.014) | 1.995 (0.369) | 0.310 (0.856) | 0.967 (0.334) | 0.610 (0.737) | |||||||||||
N1 (blunted affect) | X2 (P) | 0.877 (0.645) | 0.877 (0.645) | 1.579 (0.454) | 2.963 (0.227) | 0.723 (0.470) | 2.963 (0.227) | |||||||||||
N2 (emotional withdrawal) | X2 (P) | 2.692 (0.260) | 2.692 (0.260) | 2.830 (0.243) | 3.709 (0.157) | 0.208 (0.837) | 2.899 (0.235) | |||||||||||
N3 (poor rapport) | X2 (P) | 1.376 (0.502) | 1.376 (0.502) | 0.863 (0.649) | 1.382 (0.501) | 0.790 (0.430) | 1.337 (0.512) | |||||||||||
N4 (passive/apathetic social withdrawal) | X2 (P) | 1.886 (0.389) | 1.886 (0.389) | 3.987 (0.136) | 1.640 (0.440) | 0.487 (0.627) | 0.085 (0.958) | |||||||||||
N5 (difficulty in abstract thinking) | X2 (P) | 1.329 (0.515) | 1.329 (0.515) | 0.736 (0.692) | 2.147 (0.342) | 0.520 (0.603) | 1.537 (0.464) | |||||||||||
N6 (lack of spontaneity and flow of conversation) | X2 (P) | 0.720 (0.698) | 0.720 (0.698) | 0.019 (0.990) | 0.500 (0.779) | 0.138 (0.890) | 0.037 (0.982) | |||||||||||
N7 (stereotyped thinking) | X2 (P) | 4.471 (0.107) | 4.471 (0.107) | 3.009 (0.222) | 0.607 (0.738) | 0.554 (0.580) | 2.333 (0.311) | |||||||||||
Total of negative symptoms | X2 (P) | 2.359 (0.307) | 2.359 (0.307) | 1.404 (0.496) | 2.412 (0.299) | 0.077 (0.938) | 2.287 (0.319) | |||||||||||
G1 (somatic concern) | X2 (P) | 1.253 (0.534) | 1.253 (0.534) | 3.377 (0.185) | 3.283 (0.194) | 0.331 (0.740) | 7.148 (0.028) | |||||||||||
G2 (anxiety) | X2 (P) | 5.256 (0.072) | 5.256 (0.072) | 1.602 (0.449) | 1.266 (0.531) | 0.662 (0.508) | 0.155 (0.925) | |||||||||||
G3 (guilt feeling) | X2 (P) | 5.584 (0.061) | 5.584 (0.061) | 1.275 (0.529) | 0.008 (0.996) | 0.626 (0.531) | 2.286 (0.319) | |||||||||||
G4 (tension) | X2 (P) | 2.819 (0.244) | 2.819 (0.244) | 2.708 (0.258) | 0.810 (0.667) | 0.184 (0.854) | 0.004 (0.998) | |||||||||||
G5 (mannerisms and posturing) | X2 (P) | 0.300 (0.861) | 0.300 (0.861) | 0.539 (0.764) | 1.022 (0.600) | 0.583 (0.560) | 6.077 (0.048) | |||||||||||
G6 (depression) | X2 (P) | 4.176 (0.124) | 4.176 (0.124) | 0.276 (0.871) | 1.539 (0.463) | 0.217 (0.828) | 1.688 (0.430) | |||||||||||
G7 (motor retardation) | X2 (P) | 6.656 (0.036) | 6.656 (0.036) | 1.690 (0.430) | 0.307 (0.857) | 0.276 (0.782) | 1.384 (0.500) | |||||||||||
G8 (uncooperativeness) | X2 (P) | 3.692 (0.158) | 3.692 (0.158) | 1.840 (0.399) | 0.127 (0.938) | 0.068 (0.946) | 6.923 (0.031) | |||||||||||
G9 (unusual thought content) | X2 (P) | 5.050 (0.080) | 5.050 (0.080) | 0.839 (0.657) | 1.691 (0.429) | 0.283 (0.777) | 1.464 (0.481) | |||||||||||
G10 (disorientation) | X2 (P) | 0.371 (0.831) | 0.371 (0.831) | 2.825 (0.243) | 6.927 (0.031) | 0.433 (0.665) | 3.325 (0.190) | |||||||||||
G11 (poor attention) | X2 (P) | 6.003 (0.050) | 6.003 (0.050) | 2.197 (0.333) | 0.232 (0.890) | 0.222 (0.825) | 1.853 (0.396) | |||||||||||
G12 (lack of judgment and insight) | X2 (P) | 2.399 (0.301) | 2.399 (0.301) | 2.151 (0.341) | 1.135 (0.567) | 0.463 (0.643) | 3.279 (0.194) | |||||||||||
G13 (disturbance of volition) | X2 (P) | 3.959 (0.138) | 3.959 (0.138) | 5.174 (0.075) | 1.434 (0.488) | 0.634 (0.526) | 0.117 (0.943) | |||||||||||
G14 (poor impulse control) | X2 (P) | 1.365 (0.505) | 1.365 (0.505) | 0.354 (0.838) | 3.256 (0.196) | 0.036 (0.971) | 0.210 (0.900) | |||||||||||
G15 (preoccupation) | X2 (P) | 10.222 (0.006) | 10.222 (0.006) | 1.372 (0.504) | 0.236 (0.888) | 1.065 (0.287) | 0.649 (0.723) | |||||||||||
G16 (active social avoidance) | X2 (P) | 1.724 (0.422) | 1.724 (0.422) | 1.199 (0.549) | 1.340 (0.512) | 0.420 (0.675) | 1.087 (0.581) | |||||||||||
Total of general symptom | X2 (P) | 5.710 (0.058) | 5.710 (0.058) | 1.283 (0.527) | 0.027 (0.986) | 0.191 (0.849) | 1.415 (0.493) | |||||||||||
Positive symptoms | X2 (P) | 7.938 (0.019) | 7.938 (0.019) | 2.579 (0.275) | 2.389 (0.303) | 1.245 (0.213) | 1.617 (0.446) | |||||||||||
Negative symptoms | X2 (P) | 1.493 (0.474) | 1.493 (0.474) | 1.924 (0.382) | 3.379 (0.185) | 0.066 (0.948) | 1.888 (0.389) | |||||||||||
Cognitive impairment | X2 (P) | 0.951 (0.621) | 0.951 (0.621) | 0.525 (0.769) | 0.959 (0.619) | 0.180 (0.857) | 2.162 (0.339) | |||||||||||
Excited/hostile | X2 (P) | 2.261 (0.322) | 2.261 (0.322) | 0.937 (0.626) | 1.646 (0.439) | 0.525 (0.600) | 3.353 (0.187) | |||||||||||
Anxiety/depression | X2 (P) | 4.999 (0.082) | 4.999 (0.082) | 0.779 (0.677) | 1.293 (0.524) | 0.303 (0.762) | 0.891 (0.640) | |||||||||||
PANSS (total) | X2 (P) | 5.368 (0.068) | 5.368 (0.068) | 0.683 (0.711) | 0.953 (0.621) | 0.030 (0.976) | 2.158 (0.340) | |||||||||||