Dose Group (mg/kg) | Â | Parameter | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Concentration 1Â h after end of infusion | Ctrough | ||||||||||
Day | Day | ||||||||||
1 | 28 | 56 | 28 | 56 | |||||||
ug/mL | (ug/mL)/mg | ug/mL | (ug/mL)/mg | ug/mL | (ug/mL)/mg | ug/mL | (ug/mL)/mg | ug/mL | (ug/mL)/mg | ||
10 | N | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 |
 | Mean | 229 | 0.838 | 157 | 0.605 | 164 | 0.640 | 4.31 | 0.017 | 7.96 | 0.030 |
 | Min | 120 | 0.40 | 111 | 0.41 | 133 | 0.36 | 3.12 | 0.01 | 5.33 | 0.02 |
 | Median | 168 | 0.61 | 160 | 0.58 | 167 | 0.61 | 4.16 | 0.02 | 7.28 | 0.03 |
 | Max | 1150 | 3.52 | 189 | 0.84 | 200 | 0.90 | 7.07 | 0.02 | 11.4 | 0.04 |
 | CV% | 112 | 92.1 | 15.3 | 22.2 | 11.3 | 23.5 | 23.8 | 26.4 | 22.9 | 22.7 |
 | Geometric mean | 182 | 0.692 | 155 | 0.591 | 163 | 0.622 | 4.21 | 0.016 | 7.78 | 0.030 |
 | CV% geometric mean | 59.7 | 58.6 | 16.1 | 22.6 | 11.3 | 25.4 | 22.0 | 29.0 | 22.5 | 25.8 |
20 | N | 18 | 18 | 16 | 16 | 15 | 15 | 16 | 16 | 15 | 15 |
 | Mean | 328 | 0.51 | 327 | 0.53 | 332 | 0.52 | 11.0 | 0.018 | 21.1 | 0.033 |
 | Min | 214 | 0.15 | 193 | 0.12 | 172 | 0.13 | 6.16 | 0.00 | 7.60 | 0.01 |
 | Median | 344 | 0.52 | 330 | 0.54 | 353 | 0.58 | 11.3 | 0.02 | 24.40 | 0.04 |
 | Max | 439 | 0.92 | 470 | 0.97 | 459 | 0.77 | 14.3 | 0.03 | 30.20 | 0.05 |
 | CV% | 20.5 | 43.4 | 28.0 | 44.4 | 25.8 | 36.4 | 18.8 | 34.0 | 35.9 | 45.0 |
 | Geometric mean | 321 | 0.456 | 314 | 0.47 | 320 | 0.47 | 10.8 | 0.016 | 19.4 | 0.029 |
 | CV% geometric mean | 22.3 | 52.8 | 29.9 | 59.8 | 30.0 | 55.6 | 21.2 | 51.7 | 48.0 | 71.4 |