Fig. 1

Prevalence and factors associated with treatment discontinuation a Estimated discontinuation rates and 95% confidence intervals are shown across medications. The graph is color coded according to medication class (from left to right): SSRIs, SNRIs, and others. Purple dashed lines show the estimates for males, whereas the green solid lines show the results for females. b Heatmap depicting the odds ratio between treatment discontinuation and side effects, comorbidities, chronotype, and demographic variables. The color scale represents the odds ratios of associations between these variables and treatment discontinuation. Blue color indicates an increased risk, whereas red color indicates a decreased risk (protective effect). *Nominally significant (p-value < 0·05) odds ratio. **Significant odds ratio after Bonferroni multiple testing correction.