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Table 1 Description of the study samples

From: Predicting quetiapine dose in patients with depression using machine learning techniques based on real-world evidence

Category

Variable

Median (IQR) | n(%)

Miss rate

Quetiapine information

TDM value, ng·ml−1, median (IQR)

213.06 (124.23–370.24)

0.00%

Daily dose, median (IQR)

 

0.00%

100 (1)

57 (18.51%)

 

200 (2)

108 (35.06%)

 

300 (3)

74 (24.03%)

 

400 (4)

69 (22.40%)

 

Demographic information

Age, median (IQR)

19.00 (15.00–36.25)

0.00%

Sex, n (%)

 

0.00%

Female

177 (57.47%)

 

Male

131 (42.53%)

 

Weight, kg, median (IQR)

65.00 (55.00–76.00)

52.92%

Height, cm, median (IQR)

166.00 (160.00–172.00)

53.25%

Concomitant diseases

Hypertension, n (%)

26 (8.44%)

0.00%

Diabetes, n (%)

10 (3.25%)

0.00%

Hyperlipidemia, n (%)

22 (7.14%)

0.00%

Combination medication

CYP3A4 enzyme inhibitors, n (%)

1 (0.32%)

0.00%

CYP3A4 competitive substrates, n (%)

16 (5.19%)

0.00%

CYP2D6 competitive substrates, n (%)

30 (9.74%)

0.00%

Laboratory parameters

AFU, U/L, median (IQR)

17.20 (14.05–20.20)

9.42%

α-HBDH, U/L, median (IQR)

100.00 (89.05–114.00)

24.03%

GGT, U/L, median (IQR)

17.00 (13.00–28.00)

3.57%

ALT, U/L, median (IQR)

16.20 (10.30–29.10)

3.57%

NEUR, %, median (IQR)

51.25 (45.85–59.35)

5.19%

LDH, U/L, median (IQR)

158.00 (142.25–178.00)

24.03%

MONOR, %, median (IQR)

8.05 (6.50–9.40)

5.19%

BASOR, %, median (IQR)

0.40 (0.30–0.60)

10.06%

EOSR, %, median (IQR)

2.50 (1.70–3.60)

10.06%

AST, U/L, median (IQR)

18.50 (15.40–22.90)

3.57%

BUN, mmol·L−1, median (IQR)

3.96 (3.15–4.57)

3.57%

UA, µmol·L−1, median (IQR)

332.45 (276.80–401.45)

3.25%

MCV, fl, median (IQR)

88.60 (85.55–92.03)

5.19%

MPV, fl, median (IQR)

8.70 (8.00–9.50)

5.19%

MCHC, g·L−1, median (IQR)

338.00 (331.00–345.00)

5.19%

MCH, pg, median (IQR)

30.20 (28.80–31.20)

5.19%

TBA, µmol·L−1, median (IQR)

3.00 (1.98–5.00)

1.30%

TBIL, µmol·L−1, median (IQR)

8.50 (6.80–10.93)

1.30%

TP, g·L−1, median (IQR)

65.10 (63.00–68.95)

1.30%

LYP, %, median (IQR)

35.25 (28.55–40.75)

5.19%

LYM, 109/L, median (IQR)

2.00 (1.64–2.40)

5.19%

GLB, g·L−1, median (IQR)

24.40 (22.40–26.80)

1.30%

AIB/GLB, median (IQR)

1.68 (1.52–1.85)

1.30%

WBC, 109/L, median (IQR)

5.90 (4.97–6.80)

5.19%

AIB, g·L−1, median (IQR)

40.70 (39.00–43.00)

1.30%

DBIL, µmol·L−1, median (IQR)

1.70 (1.30–2.30)

1.30%

HCT, %, median (IQR)

37.80 (34.90–41.70)

5.19%

RBC, 1012/L, median (IQR)

4.34 (4.03–4.70)

5.19%

Cr, µmol·L−1, median (IQR)

60.30 (53.50–72.70)

3.57%

CK, U/L, median (IQR)

71.00 (52.00–101.75)

24.03%

ChE, U/L, median (IQR)

7524.00 (6640.75–8536.00)

1.30%

ADA, U/L, median (IQR)

9.50 (7.90–11.65)

9.42%

PLT, 109/L, median (IQR)

238.00 (199.75–277.25)

5.19%

Hb, g·L−1, median (IQR)

130.00 (118.00–142.00)

5.19%

IBIL, µmol·L−1, median (IQR)

6.90 (5.40–8.90)

1.30%

  1. AFU a-L-fucosidase, HBDH alpha-hydroxybutyrate dehydrogenase, GGT γ-glutamyl transpeptidase, ALT alanine aminotransferase, NEUR percentage of neutrophils, LDH lactic dehydrogenase, MONOR percentage of monocytes, BASOR percentage of basophilic granulocyte, EOSR percentage of eosinophils granulocyte, AST aspartate aminotransferase, ALT alanine aminotransferase, BUN blood urea nitrogen, UA uric acid, MCV mean corpuscular volume, MPV mean platelet volume, MCHC mean corpuscular hemoglobin concentration, MCH mean corpuscular hemoglobin, TBA total bile acid, TBIL total bilirubin, TP total protein, LYP percentage of lymphocytes, GLB globulin, WBC white blood cells, AIB albumin, DBIL direct bilirubin, RDW Red cell distribution width, HCT hematocrit, RBC red blood cell count, Cr creatinine, CK creatine kinase, ChE cholinesterase, ADA adenosine deaminase, Hb hemoglobin, IBIL Indirect Bilirubin
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Annals of General Psychiatry

ISSN: 1744-859X