Real-world predictors of divorce among outpatients with bipolar disorder: sex differences and clinical implications

Tokumitsu, Keita; Sugawara, Norio; Adachi, Naoto; Kubota, Yukihisa; Watanabe, Yoichiro; Miki, Kazuhira; Azekawa, Takaharu; Edagawa, Koji; Katsumoto, Eiichi; Hongo, Seiji; Goto, Eiichiro; Ueda, Hitoshi; Kato, Masaki; Yoshimura, Reiji; Nakagawa, Atsuo; Kikuchi, Toshiaki; Tsuboi, Takashi; Watanabe, Koichiro; Yasui-Furukori, Norio

doi:10.1186/s12991-023-00487-6

Annals of General Psychiatry

Table 2 Binomial logistic regression analysis of factors for divorce among all participants

From: Real-world predictors of divorce among outpatients with bipolar disorder: sex differences and clinical implications

Variables in the equation	Coefficient	Standard error	Wald value	p value	Odds ratio (95% confidence interval)
Sex (being male)	0.952	0.513	3.438	0.064	2.590 (0.947–7.084)
BMI at baseline	−0.128	0.063	4.092	0.043	0.880 (0.777–0.996)
Age at baseline	−0.061	0.029	4.383	0.036	0.941 (0.888–0.996)
Age of onset	−0.013	0.030	0.174	0.676	0.987 (0.931–1.048)
Bipolar disorder subcategories (reference; Bipolar I disorder)			1.527	0.466
Bipolar II disorder	−0.630	0.526	1.438	0.231	0.532 (0.190–1.492)
Unclassifiable	−0.166	0.975	0.029	0.865	0.847 (0.125–5.731)
Work status at baseline (employed)	−0.804	0.612	1.728	0.189	0.448 (0.135–1.484)
Educational background (reference; Junior college, technical college, or higher)			2.175	0.337
Special support education school, junior high school	−16.498	5499.370	0.000	0.998	0.000 (0.000-Infinity)
High school, vocational school	0.706	0.479	2.175	0.140	2.026 (0.793–5.179)
Mood status(reference; Depressive state)			1.886	0.596
Manic/hypomanic state	0.457	0.963	0.225	0.635	1.579 (0.239–10.423)
Mixed feature	−0.106	0.956	0.012	0.912	0.900 (0.138–5.856)
Remission	−0.719	0.629	1.310	0.252	0.487 (0.142–1.670)
Intelligence quotient (85 or less)	−17.084	5938.844	0.000	0.998	0.000 (0.000–Infinity)
Global Assessment of Functioning (reference; 81–100)			1.337	0.513
61–80	−0.312	0.614	0.258	0.612	0.732 (0.220–2.438)
1–60	−1.154	1.008	1.311	0.252	0.315 (0.044–2.274)
Mood stabilizers prescription	−0.662	0.499	1.761	0.184	0.516 (0.194–1.371)
Antipsychotics prescription	0.399	0.484	0.679	0.410	1.490 (0.577–3.848)
Antidepressants prescription	0.578	0.505	1.312	0.252	1.782 (0.663–4.793)
Anxiolytics prescription	0.657	0.475	1.918	0.166	1.930 (0.761–4.893)
Hypnotics prescription	−0.227	0.491	0.213	0.645	0.797 (0.304–2.088)
Rapid cycler at baseline	0.433	0.937	0.214	0.644	1.542 (0.246–9.672)
Manic symptoms during 1 year before baseline	−0.410	0.697	0.346	0.557	0.664 (0.169–2.601)
Hospitalization during 1 year before baseline	−17.577	7622.567	0.000	0.998	0.000 (0.000–Infinity)
Personality disorder	1.225	0.799	2.350	0.125	3.404 (0.711–16.296)
Developmental disorder	−17.574	6004.819	0.000	0.998	0.000 (0.000–Infinity)
Physical comrbidity	0.014	0.545	0.001	0.980	1.014 (0.349–2.948)
Substance abuse	−0.516	1.223	0.178	0.673	0.597 (0.054–6.565)
Psychotic feature	−0.753	1.131	0.443	0.506	0.471 (0.051–4.324)
Suicidal ideation	0.963	0.888	1.176	0.278	2.620 (0.46–14.938)
Constant	3.445	2.093	2.710	0.100

p < 0.05 was regarded as statistically significant using binomial logistic regression with forced entry

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ISSN: 1744-859X

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