Real-world predictors of divorce among outpatients with bipolar disorder: sex differences and clinical implications

Tokumitsu, Keita; Sugawara, Norio; Adachi, Naoto; Kubota, Yukihisa; Watanabe, Yoichiro; Miki, Kazuhira; Azekawa, Takaharu; Edagawa, Koji; Katsumoto, Eiichi; Hongo, Seiji; Goto, Eiichiro; Ueda, Hitoshi; Kato, Masaki; Yoshimura, Reiji; Nakagawa, Atsuo; Kikuchi, Toshiaki; Tsuboi, Takashi; Watanabe, Koichiro; Yasui-Furukori, Norio

doi:10.1186/s12991-023-00487-6

Annals of General Psychiatry

Table 4 Binomial logistic regression analysis of factors for divorce among female participants

From: Real-world predictors of divorce among outpatients with bipolar disorder: sex differences and clinical implications

Variables in the equation	Coeffiecitnet	Standard error	Wald value	p value	Odds ratio (95% conficence interval)
BMI at baseline	−0.399	0.161	6.167	0.013	0.671 (0.49–0.919)
Age at baseline	0.023	0.046	0.257	0.612	1.024 (0.935–1.120)
Age of onset	−0.078	0.054	2.107	0.147	0.925 (0.832–1.028)
Bipolar disorder subcategories (reference; Bipolar I disorder)			1.763	0.414
Bipolar II disorder	16.597	2545.681	0.000	0.995	1.614*10⁷(0.000–Infinity)
Unclassifiable	18.236	2545.681	0.000	0.994	8.315*10⁷(0.000–Infinity)
Work status at baseline (employed)	−1.361	1.020	1.778	0.182	0.257 (0.035–1.895)
Educational background (reference; Junior college, technical college, or higher)			0.023	0.989
Special support education school, junior high school	−16.103	5529.838	0.000	0.998	0.000 (0.000–Infinity)
High school, vocational school	−0.131	0.871	0.023	0.880	0.877 (0.159–4.833)
Mood status(reference; Depressive state)			1.228	0.746
Manic/hypomanic state	−15.843	5301.560	0.000	0.998	0.000 (0.000–Infinity)
Mixed feature	−2.353	2.123	1.228	0.268	0.095 (0.001–6.101)
Remission	−0.092	1.084	0.007	0.933	0.912 (0.109–7.638)
Intelligence quotient (85 or less)	−18.885	6198.986	0.000	0.998	0.000 (0.000-Infinity)
Global assessment of functioning (reference; 81–100)			0.004	0.998
61–80	−0.061	1.099	0.003	0.956	0.941 (0.109–8.102)
1–60	0.000	1.714	0.000	1.000	1.000 (0.035–28.764)
Mood stabilizers prescription	−0.734	0.871	0.710	0.399	0.480 (0.087–2.647)
Antipsychotics prescription	0.030	0.870	0.001	0.972	1.031 (0.187–5.669)
Antidepressants prescription	0.096	0.901	0.011	0.915	1.101 (0.188–6.438)
Anxiolytics prescription	1.737	0.878	3.910	0.048	5.678 (1.015–31.751)
Hypnotics prescription	0.570	0.873	0.425	0.514	1.768 (0.319–9.793)
Rapid cycler at baseline	−17.698	3840.923	0.000	0.996	0.000 (0.000–Infinity)
Manic symptoms during 1 year before baseline	−0.440	1.284	0.117	0.732	0.644 (0.052–7.975)
Hospitalization during 1 year before baseline	−19.559	7102.789	0.000	0.998	0.000 (0.000–Infinity)
Personality disorder	1.322	1.595	0.687	0.407	3.751 (0.165–85.477)
Developmental disorder	−15.223	6748.552	0.000	0.998	0.000 (0.000–Infinity)
Physical comrbidity	0.554	1.011	0.300	0.584	1.74 (0.240–12.615)
Substance abuse	−15.642	8356.816	0.000	0.999	0.000 (0.000–Infinity)
Psychotic feature	−17.811	5717.615	0.000	0.998	0.000 (0.000–Infinity)
Suicidal ideation	2.067	1.489	1.927	0.165	7.902 (0.427–146.292)
Constant	−10.098	2545.684	0.000	0.997

p < 0.05 was regarded as statistically significant using binomial logistic regression with forced entry

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ISSN: 1744-859X

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