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Table 1 Concentrations (mmol/kg wet brain) and ratios (Cho/Cre) in frontal and temporal lobes in healthy volunteers and in patients chronically treated with valproate (Study #2)

From: Brain choline concentrations may not be altered in euthymic bipolar disorder patients chronically treated with either lithium or sodium valproate

   

Choline (Cho)

Creatine (Cre)

Cho/Cre

   

Frontal

Temporal

Frontal

Temporal

Frontal

Temporal

Healthy Controls

Age

Sex

      

1

50

M

3.51

2.95

6.67

8.53

0.53

0.35

2

45

M

2.19

3.03

10.1

9.11

0.22

0.33

3

43

F

3.01

2.31

9.97

9.52

0.30

0.24

4

39

M

2.11

2.72

7.94

7.60

0.27

0.24

5

37

F

2.47

2.34

9.98

9.89

0.25

0.24

6

36

F

1.91

1.76

8.28

8.19

0.23

0.22

7

35

M

1.76

2.36

7.93

8.36

0.22

0.28

8

32

F

1.88

1.51

9.56

9.56

0.2

0.16

9

32

M

1.94

2.14

7.04

7.79

0.28

0.28

10

30

F

1.82

2.52

7.8

8.63

0.23

0.29

11

28

M

1.72

2.23

7.16

8.51

0.24

0.26

Mean

37.00

 

2.21

2.35

8.40

8.70

0.27

0.26

Valproate Treated Patients

      

1

58

F

2.72

2.1

9.16

10.13

0.30

0.21

2

50

M

2.61

3.42

8.17

10.53

0.32

0.33

3

49

F

2.03

1.79

8.56

7.48

0.24

0.24

4

48

F

2.44

1.88

9.93

8.19

0.25

0.23

5

36

M

2.60

2.53

7.84

7.51

0.33

0.34

6

35

F

2.07

2.77

9.26

10.39

0.22

0.27

7

35

F

2.78

1.89

8.35

9.79

0.33

0.19

8

34

F

1.76

2.93

7.26

8.01

0.24

0.37

9

34

F

2.43

2.27

7.75

7.23

0.31

0.31

Mean

42.11

 

2.38

2.40

8.48

8.81

0.28

0.28