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Table 1 Demographic and clinical features week 12 comparison of responders vs non-responders

From: An open pilot study of zonisamide augmentation in major depressive patients not responding to a low dose trial with duloxetine: preliminary results on tolerability and clinical effects

  Responders, N = 15 (38.5%) Non-responders, N = 24 (61.5%) t or χ 2 (df = 1) P value
Age, mean(s) 41.33 ± 9.5 50.7 ± 0.2 2.865 NS
General features F = 9; M = 6 F = 1; M = 23 -0.152 NS
Weight (in kg) 68.4 ± 15.71 68.29 ± 12.11 36 NS
Clinical features (%)
HAM-D total score 4.27 ± 3.15 13.71 ± 2.53 10.320 0.001
HAM-A total score 6.60 ± 3.58 12.83 ± 4.76 4.351 0.001
YMRS total score 1.93 ± 1.62 3.21 ± 1.16 2.394 0.022
ASEX total score 18.20 ± 5.69 18.58 ± 4.87 0.224 NS
Side effects profile (%)
Diarrhea 0 4 (10.25%) 2.786 NS
Tremors 0 2 (5.12%) 1.318 NS
Poor coordination 0 2 (5.12%) 1.318 NS
Dizziness 0 4 (10.25%) 2.786 NS
Blurred vision 3 (7.7%) 6 (15.4%) 0.130 NS
Ringing in ears 4 (10.25%) 0 7.131 0.008
Difficult urination 4 (10.25%) 2 (5.12%) 2.383 NS
Painful urination 0 2 (5.12%) 1.318 NS
Pollachiuria 1 (2.6%) 2 (5.12%) 0.036 NS
Menstrual irregularity 0 0 - -
Insomnia 11 (28.2%) 18 (46.15%) 0.013 NS
Hypersomnia 0 4 (10.25%) 2.786 NS
Loss of libido 4 (10.25%) 12 (30.77%) 2.077 NS
Anorgasmy 4 (10.25%) 18 (46.15%) 8.770 0.003
Erectile dysfunction 0 0 - -
Poor concentration 1 (2.6%) 16 (41%) 13.514 0.001
General malaise 0 14 (35.9%) 13.650 0.001
Reduced energy 3 (7.7%) 12 (30.77%) 3.510 NS
Hyperphagia 2 (5.12%) 4 (10.25%) 0.079 NS
  1. ASEX = Arizona Sexual Experience Scale; HAM-A = Hamilton Anxiety Scale; HAM-D = Hamilton Depression Scale; NS = not significant; YMRS = Young Mania Rating Scale.