Figure 2

Schematic hypothesis, in conditions of platelet membrane fatty acid modifications, of the serotonin pathway, from enterochromaffin cells (ECs) to platelets, and regulation of the interactome through the membrane viscosity. When platelets reach a very high concentration of arachidonic acid, exchanges of arachidonic acid between platelets and the brain and vice versa are not possible; arachidonic acid increases in the brain and neurons, and platelet membranes become very fluid (loss of viscosity) impairing serotonin uptake in both cells.