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Table 6 Serum cytokine concentrations in 41 perimenopausal women with depression subdivided into five groups according to the presence and severity of hot flashes (Menopause Rating Scale)

From: The role of cytokines and hot flashes in perimenopausal depression

Cytokine Hot flashes P value, Kruskal-Wallis
  Without, (n = 2) Mild, (n = 7) Moderate, (n = 6) Severe, (n = 17) s Very severe, (n = 9)  
TNFα 0.00 (true zero) 4.61 (1.84 to 7.35) 7.35 8.99 (4.65 to 14.30) 13.19 (7.12 to 21.90) 0.583, NS
IL-6 0.00 (true zero) 1.44 (1.44 to 1.44) 1.13 2.50 (1.44 to 4.67) 2.11 (1.50 to 2.95) 0.719, NS
IL-10 0.00 (true zero) 0.00 (true zero) 4.54 4.96 (3.10 to 10.20) 6.83 (3.44 to 12.00) 0.745, NS
  1. The results of cytokines are expressed as medians (10% to 90%). Unit of serum cytokine concentration is pg/ml.
  2. IL = interleukin; NS = not significant; TNF = tumor necrosis factor.