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# Table 1
**Estimation of the overall effectiveness and magnitude of heterogeneity**

From: No role for initial severity on the efficacy of antidepressants: results of a multi-meta-analysis

Analyses | Effect size (CI/CrI) | Heterogeneity (CrI) | Role for initial severity | Respects randomisation | |||
---|---|---|---|---|---|---|---|

RMD | SMD | RMD | SMD | RMD | SMD | ||

Frequentist methods | |||||||

Simple random effects meta-analysis | 2.71 (1.96, 3.45) | 0.33 (0.24, 0.42) | 2.50 | 0.03 | Yes | ||

NMA random effects analysis | 2.31 | 0.03 | Yes | ||||

Meta-regression random effects analysis | 1.57 | 0.02 | Yes | Yes | Yes | ||

Turner et al. (random effects meta-analysis) | - | 0.31 (0.27, 0.35) | - | - | - | - | Yes |

Khan et al., ratio of the number of early discontinued patients divided by the total number of patients in each group (chi-square is also calculated) | - | - | - | - | Yes | Yes | No |

Kirsch et al. (weight by sample size/SD^{2})
| 1.80 | 0.32 | - | - | - | Yes | No |

Horder et al. (random effects meta-analysis) | 2.70 (1.95, 3.44) | - | - | - | Yes | - | Meta-analysis: yes |

Meta-regression: no | |||||||

Fountoulakis et al. (sample size weighting) | 2.18 | 0.32 | - | - | - | - | No |

Fountoulakis et al. (inverse variance weighting) | 2.68 | 0.35 | - | - | - | - | No |

Bayesian methods | |||||||

Simple random effects meta-analysis | 2.61 (1.94, 3.30) | 0.32 (0.25, 0.40) | 1.61 (0.53, 3.53) | 0.02 (0.00, 0.05) | Yes | ||

NMA random effects analysis | 0.71 (0.24, 0.98) | 0.01 (0.00, 0.05) | Yes | ||||

Simple random effects meta-regression analysis | 2.77 (2.18, 3.36) | 0.34 (0.27, 0.42) | 0.58 (0.00, 2.13) | 0.01 (0.00, 0.05) | Yes | No | Yes |

Simple random effects meta-regression analysis using 12 different priors | Yes | No | Yes | ||||

NMA random effects meta-regression analysis | 0.59 (0.01, 2.19) | 0.01 (0.00, 0.05) | Yes | No | Yes | ||

NMA random effects meta-regression using 12 different priors | Yes | No | Yes |