Table 2 Sociodemographic, clinical, cognitive and neurophysiological values according to NRG1 rs6994992 and rs3924999, and NRG3 rs10748842 genotypes
From: Cognitive outcome and gamma noise power unrelated to neuregulin 1 and 3 variation in schizophrenia
NRG1 rs6994992 | NRG1 rs3924999 | NRG3 rs10748842 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Patients | Healthy controls | Patients | Healthy controls | Patients | Healthy controls | |||||||
T + (N = 21) | T − (N = 10) | T + (N = 12) | T − (N = 11) | A + (N = 18) | A − (N = 13) | A + (N = 16) | A − (N = 7) | C + (N = 8) | C − (N = 23) | C + (N = 4) | C − (N = 19) | |
Age (years) | 36.24 (12.26) | 36.80 (12.33) | 33.92 (14.86) | 29.73 (11.25) | 35.50 (14.02) | 37.69 (9.10)* | 33.69 (13.42) | 27.86 (12.44) | 35.38 (8.40) | 36.78 (13.26) | 40.25 (21.22) | 30.16 (10.82) |
Total IQ | 82.16 (15.85)*** | 80.67 (10.62)** | 101.92 (11.91) | 106.27 (14.50) | 81.13 (14.74)*** | 82.42 (14.04)** | 104.19 (14.10) | 103.57 (11.47) | 83.67 (10.58)* | 81.14 (15.20)*** | 106.25 (14.34) | 103.53 (13.19) |
PANSS positive | 20.05 (3.56) | 20.75 (6.14) | N/A | N/A | 20.94 (4.48) | 19.33 (4.14) | N/A | N/A | 19.86 (5.11) | 20.38 (4.18) | N/A | N/A |
PANSS negative | 20.10 (5.77) | 18.63 (5.13) | N/A | N/A | 17.69 (5.10)* | 22.33 (5.14) | N/A | N/A | 20.29 (7.89) | 19.48 (4.75) | N/A | N/A |
PANSS total | 75.75 (11.00) | 74.75 (15.37) | N/A | N/A | 71.88 (11.62) | 80.25 (11.48) | N/A | N/A | 75.00 (11.66) | 75.62 (12.53) | N/A | N/A |
BACS verbal memory | 35.44 (14.14)** | 37.50 (8.90)*** | 51.75 (8.71) | 58.27 (4.69) | 37.53 (13.30)*** | 34.09 (11.09)* | 55.50 (6.61) | 53.43 (10.18) | 34.86 (14.04) | 36.62 (12.12)*** | 50.25 (9.91) | 55.84 (7.07) |
BACS working memory | 16.33 (5.82)** | 18.11 (3.48)* | 22.17 (4.34) | 22.18 (3.25) | 17.13 (5.15)** | 16.67 (5.38) | 22.50 (3.18) | 21.43 (5.09) | 16.83 (4.54)* | 16.95 (5.43)** | 23.00 (1.41) | 22.00 (4.11) |
BACS motor speed | 48.63 (17.03)* | 53.30 (12.37) | 65.33 (15.69) | 63.82 (14.60) | 52.18 (14.63) | 47.50 (16.95)** | 60.75 (14.23) | 73.43 (13.10) | 50.43 (13.76) | 50.18 (16.34)** | 59.50 (23.74) | 65.68 (12.98) |
BACS verbal fluency | 16.32 (5.38)*** | 16.60 (3.53)*** | 25.17 (5.37) | 25.82 (4.42) | 16.12 (5.13)*** | 16.83 (4.34)* | 27.13 (3.38) | 21.71 (5.79) | 17.43 (3.60)** | 16.09 (5.10)*** | 27.75 (4.35) | 25.00 (4.91) |
BACS processing speed | 38.33 (17.47)** | 35.50 (8.25)*** | 57.17 (11.47) | 60.09 (13.42) | 38.24 (16.74)*** | 35.91 (11.53)** | 60.13 (13.02) | 55.00 (10.21) | 37.86 (14.46) | 37.14 (15.15)*** | 49.75 (5.44) | 60.42 (12.54) |
BACS problem solving | 13.41 (5.48) | 10.50 (7.00)* | 16.92 (3.06) | 18.18 (3.16) | 11.50 (6.20)** | 13.55 (6.09) | 17.25 (3.32) | 18.14 (2.67) | 12.86 (5.61) | 12.15 (6.42)** | 15.75 (3.77) | 17.89 (2.92) |
P3b valid segments (n) | 45.76 (18.53) | 43.00 (26.62) | 53.25 (25.03) | 61.36 (24.33) | 43.00 (21.01) | 47.46 (21.68) | 54.94 (25.72) | 62.14 (22.41) | 47.38 (27.51) | 44.00 (18.99) | 54.00 (17.42) | 57.79 (26.07) |
Pz amplitude S2 (P3a; μV) | 0.968 (1.127) | 0.666 (1.154) | 1.485 (0.762) | 1.093 (1.179) | 0.929 (1.193) | 0.789 (1.066) | 1.210 (0.982) | 1.497 (1.025) | 0.707 (1.052) | 0.927 (1.167) | 1.114 (0.691) | 1.336 (1.043) |
Pz amplitude S3 (P3b; μV) | 0.735 (1.509)** | 0.983 (1.814) | 2.033 (0.680) | 1.827 (1.136) | 0.769 (1.449)* | 0.878 (1.821)* | 1.623 (0.873) | 2.647 (0.532) | 0.623 (1.553)* | 0.882 (1.628)* | 1.915 (0.400) | 1.939 (0.993) |
Gamma Noise Power F3 (μV2) | 0.012 (0.012) | 0.011 (0.011) | 0.007 (0.003) | 0.013 (0.022) | 0.014 (0.014)* | 0.009 (0.005) | 0.007 (0.005) | 0.016 (0.026) | 0.013 (0.012)* | 0.011 (0.012) | 0.004 (0.000) | 0.011 (0.016) |
Gamma Noise Power F4 (μV2) | 0.009 (0.006) | 0.018 (0.021) | 0.006 (0.003) | 0.011 (0.013) | 0.015 (0.017) | 0.007 (0.003) | 0.007 (0.004) | 0.012 (0.016) | 0.013 (0.016) | 0.011 (0.012) | 0.005 (0.001) | 0.009 (0.010) |
Gamma Noise Power P3 (μV2) | 0.011 (0.009)* | 0.015 (0.010)** | 0.006 (0.003) | 0.007 (0.004) | 0.013 (0.010)** | 0.012 (0.008) | 0.006 (0.004) | 0.006 (0.002) | 0.013 (0.009)* | 0.012 (0.010)** | 0.004 (0.002) | 0.007 (0.004) |
Gamma Noise Power P4 (μV2) | 0.012 (0.008)* | 0.011 (0.005) | 0.007 (0.005) | 0.007 (0.004) | 0.013 (0.009)** | 0.009 (0.003) | 0.007 (0.004) | 0.009 (0.006) | 0.011 (0.006) | 0.012 (0.008)* | 0.005 (0.004) | 0.008 (0.005) |