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Table 2 Sociodemographic, clinical, cognitive and neurophysiological values according to NRG1 rs6994992 and rs3924999, and NRG3 rs10748842 genotypes

From: Cognitive outcome and gamma noise power unrelated to neuregulin 1 and 3 variation in schizophrenia

  NRG1 rs6994992 NRG1 rs3924999 NRG3 rs10748842
  Patients Healthy controls Patients Healthy controls Patients Healthy controls
  T + (N = 21) T − (N = 10) T + (N = 12) T − (N = 11) A + (N = 18) A − (N = 13) A + (N = 16) A − (N = 7) C + (N = 8) C − (N = 23) C + (N = 4) C − (N = 19)
Age (years) 36.24 (12.26) 36.80 (12.33) 33.92 (14.86) 29.73 (11.25) 35.50 (14.02) 37.69 (9.10)* 33.69 (13.42) 27.86 (12.44) 35.38 (8.40) 36.78 (13.26) 40.25 (21.22) 30.16 (10.82)
Total IQ 82.16 (15.85)*** 80.67 (10.62)** 101.92 (11.91) 106.27 (14.50) 81.13 (14.74)*** 82.42 (14.04)** 104.19 (14.10) 103.57 (11.47) 83.67 (10.58)* 81.14 (15.20)*** 106.25 (14.34) 103.53 (13.19)
PANSS positive 20.05 (3.56) 20.75 (6.14) N/A N/A 20.94 (4.48) 19.33 (4.14) N/A N/A 19.86 (5.11) 20.38 (4.18) N/A N/A
PANSS negative 20.10 (5.77) 18.63 (5.13) N/A N/A 17.69 (5.10)* 22.33 (5.14) N/A N/A 20.29 (7.89) 19.48 (4.75) N/A N/A
PANSS total 75.75 (11.00) 74.75 (15.37) N/A N/A 71.88 (11.62) 80.25 (11.48) N/A N/A 75.00 (11.66) 75.62 (12.53) N/A N/A
BACS verbal memory 35.44 (14.14)** 37.50 (8.90)*** 51.75 (8.71) 58.27 (4.69) 37.53 (13.30)*** 34.09 (11.09)* 55.50 (6.61) 53.43 (10.18) 34.86 (14.04) 36.62 (12.12)*** 50.25 (9.91) 55.84 (7.07)
BACS working memory 16.33 (5.82)** 18.11 (3.48)* 22.17 (4.34) 22.18 (3.25) 17.13 (5.15)** 16.67 (5.38) 22.50 (3.18) 21.43 (5.09) 16.83 (4.54)* 16.95 (5.43)** 23.00 (1.41) 22.00 (4.11)
BACS motor speed 48.63 (17.03)* 53.30 (12.37) 65.33 (15.69) 63.82 (14.60) 52.18 (14.63) 47.50 (16.95)** 60.75 (14.23) 73.43 (13.10) 50.43 (13.76) 50.18 (16.34)** 59.50 (23.74) 65.68 (12.98)
BACS verbal fluency 16.32 (5.38)*** 16.60 (3.53)*** 25.17 (5.37) 25.82 (4.42) 16.12 (5.13)*** 16.83 (4.34)* 27.13 (3.38) 21.71 (5.79) 17.43 (3.60)** 16.09 (5.10)*** 27.75 (4.35) 25.00 (4.91)
BACS processing speed 38.33 (17.47)** 35.50 (8.25)*** 57.17 (11.47) 60.09 (13.42) 38.24 (16.74)*** 35.91 (11.53)** 60.13 (13.02) 55.00 (10.21) 37.86 (14.46) 37.14 (15.15)*** 49.75 (5.44) 60.42 (12.54)
BACS problem solving 13.41 (5.48) 10.50 (7.00)* 16.92 (3.06) 18.18 (3.16) 11.50 (6.20)** 13.55 (6.09) 17.25 (3.32) 18.14 (2.67) 12.86 (5.61) 12.15 (6.42)** 15.75 (3.77) 17.89 (2.92)
P3b valid segments (n) 45.76 (18.53) 43.00 (26.62) 53.25 (25.03) 61.36 (24.33) 43.00 (21.01) 47.46 (21.68) 54.94 (25.72) 62.14 (22.41) 47.38 (27.51) 44.00 (18.99) 54.00 (17.42) 57.79 (26.07)
Pz amplitude S2 (P3a; μV) 0.968 (1.127) 0.666 (1.154) 1.485 (0.762) 1.093 (1.179) 0.929 (1.193) 0.789 (1.066) 1.210 (0.982) 1.497 (1.025) 0.707 (1.052) 0.927 (1.167) 1.114 (0.691) 1.336 (1.043)
Pz amplitude S3 (P3b; μV) 0.735 (1.509)** 0.983 (1.814) 2.033 (0.680) 1.827 (1.136) 0.769 (1.449)* 0.878 (1.821)* 1.623 (0.873) 2.647 (0.532) 0.623 (1.553)* 0.882 (1.628)* 1.915 (0.400) 1.939 (0.993)
Gamma Noise Power F3 (μV2) 0.012 (0.012) 0.011 (0.011) 0.007 (0.003) 0.013 (0.022) 0.014 (0.014)* 0.009 (0.005) 0.007 (0.005) 0.016 (0.026) 0.013 (0.012)* 0.011 (0.012) 0.004 (0.000) 0.011 (0.016)
Gamma Noise Power F4 (μV2) 0.009 (0.006) 0.018 (0.021) 0.006 (0.003) 0.011 (0.013) 0.015 (0.017) 0.007 (0.003) 0.007 (0.004) 0.012 (0.016) 0.013 (0.016) 0.011 (0.012) 0.005 (0.001) 0.009 (0.010)
Gamma Noise Power P3 (μV2) 0.011 (0.009)* 0.015 (0.010)** 0.006 (0.003) 0.007 (0.004) 0.013 (0.010)** 0.012 (0.008) 0.006 (0.004) 0.006 (0.002) 0.013 (0.009)* 0.012 (0.010)** 0.004 (0.002) 0.007 (0.004)
Gamma Noise Power P4 (μV2) 0.012 (0.008)* 0.011 (0.005) 0.007 (0.005) 0.007 (0.004) 0.013 (0.009)** 0.009 (0.003) 0.007 (0.004) 0.009 (0.006) 0.011 (0.006) 0.012 (0.008)* 0.005 (0.004) 0.008 (0.005)
  1. No within-group significant differences were detected between patients or HC subgroups classified according to their genotype. Differences between patients and HC with the same SNP variation are displayed in the Patients column. Data exhibited as Mean (S.D.); *p < 0.05; **p < 0.01; ***p < 0.001; Significant results after Bonferroni correction (p < 0.00138) are in italics (Mann-Whitney's U test); N/A, not applicable.