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Table 3 Frequency of different medication classes within second-step switch or add-on treatments

From: What happens next?: a claims database study of second-line pharmacotherapy in patients with major depressive disorder (MDD) who initiate selective serotonin reuptake inhibitor (SSRI) treatment

Medication class Second-step switch Second-step add-on
(N = 771) (N = 1,894)
n(%) n(%)
Antidepressants   
 SNRI 195 (25.3) 76 (4.0)
 Bupropion 186 (24.1) 292 (15.4)
 Tricyclic antidepressants 53 (6.9) 299 (15.8)
 Other antidepressantsa 27 (3.5) 35 (1.8)
 Total (antidepressants) 461 (59.8) 702 (37.1)
Anxiolytics   
 Benzodiazepine 138 (17.9) 727 (38.4)
 Buspirone 10 (1.3) 34 (1.8)
 Total (anxiolytics) 148 (19.2) 761 (40.2)
Anticonvulsants 47 (6.1) 106 (5.6)
Lithium 4 (0.5) 6 (0.3)
Second-generation antipsychotics   
 Quetiapine 15 (1.9) 43 (2.3)
 Aripiprazole 9 (1.2) 65 (3.4)
 Other second-generation antipsychoticsb 2 (0.3) 45 (2.4)
 Total (antipsychotics) 26 (3.4) 153 (8.1)
Stimulants 10 (1.3) 35 (1.8)
Norepinephrine reuptake inhibitor 3 (0.4) 10 (0.5)
 Two-drug combination   
  Anxiolytic + antidepressant 33 (4.2) 42 (2.2)
  Second-generation AP + antidepressant 8 (1.0) 15 (0.8)
  Two antidepressants 9 (1.2) 9 (0.5)
  Second-generation AP + anxiolytic 0 (0) 15 (0.8)
  Other 16 (2.1) 35 (1.9)
  Total two-drug combinations 66 (8.6) 116 (6.12)
 Combination of three or more drugs 6 (0.8) 5 (0.3)
  1. AP antipsychotic. aOther antidepressants include nefazadone hydrochloride and mirtazapine; bother second-generation antipsychotics include olanzapine, risperidone, and ziprasidone.