Medication class | Second-step switch | Second-step add-on |
---|---|---|
(N = 771) | (N = 1,894) | |
n(%) | n(%) | |
Antidepressants | ||
SNRI | 195 (25.3) | 76 (4.0) |
Bupropion | 186 (24.1) | 292 (15.4) |
Tricyclic antidepressants | 53 (6.9) | 299 (15.8) |
Other antidepressantsa | 27 (3.5) | 35 (1.8) |
Total (antidepressants) | 461 (59.8) | 702 (37.1) |
Anxiolytics | ||
Benzodiazepine | 138 (17.9) | 727 (38.4) |
Buspirone | 10 (1.3) | 34 (1.8) |
Total (anxiolytics) | 148 (19.2) | 761 (40.2) |
Anticonvulsants | 47 (6.1) | 106 (5.6) |
Lithium | 4 (0.5) | 6 (0.3) |
Second-generation antipsychotics | ||
Quetiapine | 15 (1.9) | 43 (2.3) |
Aripiprazole | 9 (1.2) | 65 (3.4) |
Other second-generation antipsychoticsb | 2 (0.3) | 45 (2.4) |
Total (antipsychotics) | 26 (3.4) | 153 (8.1) |
Stimulants | 10 (1.3) | 35 (1.8) |
Norepinephrine reuptake inhibitor | 3 (0.4) | 10 (0.5) |
Two-drug combination | ||
Anxiolytic + antidepressant | 33 (4.2) | 42 (2.2) |
Second-generation AP + antidepressant | 8 (1.0) | 15 (0.8) |
Two antidepressants | 9 (1.2) | 9 (0.5) |
Second-generation AP + anxiolytic | 0 (0) | 15 (0.8) |
Other | 16 (2.1) | 35 (1.9) |
Total two-drug combinations | 66 (8.6) | 116 (6.12) |
Combination of three or more drugs | 6 (0.8) | 5 (0.3) |