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Table 2 Characteristics of the studies included in the review

From: Review of the use of Topiramate for treatment of psychiatric disorders

Condition Number of studies Design Outcome
Bipolar disorders    
Bipolar mania 8 5 controlled (*) Negative
   3 open label (70–72) Positive
Rapid-cycling bipolar disorders 1 Open label, add-on (75) Positive
Adjunctive therapy (refractory bipolar disorders) 12 Open label (76–87) Positive
Bipolar depression 2 1 Controlled, add-on (88) Positive
   1 Open label, add-on (89) Positive
Bipolar disorders in children and adolescents as adjunctive treatment 1 Open label, add-on (90) Positive
Unipolar depression 2 1 Case report (91) Negative
   1 Chart review (92) Positive
Schizophrenia, schizoaffective disorders and psychosis unspecified 3 2 Case series (93, 94) Negative
   1 Case report (95) Positive
Eating disorders and disordered eating 4 2 Controlled (96, 97) Positive
   1 Open label, add on (98) Positive
   1 Case series, add on (99) Positive
Posttraumatic stress disorder 1 Open label, add on (100) Positive
Alcohol dependence 1 Controlled (101) Positive
Gilles de la Tourette's syndrome 1 Case series (102) Positive
Emotional unstable personality disorder 1 Case reports (103) Positive
  1. (*) Unpublished