SSRI's
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Swartz et al 1997: 11 patients; open-label (sertraline, paroxetine, fluoxetine)
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9/11 had behavioral improvement
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Diarrhea (1/11) Increased anxiety (1/11)
|
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Moretti et al 2003: 8 patients; open-label (paroxetine)
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Behavioral improvement Reduced caregiver burden
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Transient nausea (37.5%)
|
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Deakin et al 2004: 10 patients; RCTa (paroxetine)
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No improvement in NPIb or CBIc scores Impairment seen on learning tasks/recognition tasks
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None reported
|
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Ikeda et al 2004: 16 patients; open-label (fluvoxamine)
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Behavioral improvement Decreased stereotypes
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None reported
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Trazodone
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Lebert et al 1999: 14 patients; open-label
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Improvement in delusions, irritability, aggression, disinhibition (dose-dependent)
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None reported
|
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Lebert et al 2004: 26 patients; randomized controlled trial
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Improvement in irritability, agitation, depression, eating disorders
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None reported
|
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Lebert et al 2006: 26 patients; open-label extension of 2004 RCT
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Improved behavioral symptoms; improved NPI score
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Hypotension (15%)
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Antipsychotics
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Curtis et al 2000: 1 patient; case report (risperidone)
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Improved psychosis and social interactions
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Akathisia Mild parkinsonism
|
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Pijnenburg et al 2003: 24 patients; retrospective chart review (majority of patients given typical antipsychotics)
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Not reported
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Extrapyramidal symptoms (33%) Sedation (12.5%)
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Others
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Moretti et al 2004: 20 patients; open-label (rivastigmine)
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Improved behavioral symptoms Reduced caregiver burden No change in MMSEd score
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Nausea (25%) Muscle cramps (20%) Blood pressure changes (15%)
|
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Goforth et al 2004: 1 patient; case report (methylphenidate)
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Improved behavioral symptoms
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None reported
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