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Table 3 Effect of chronic dioscorea administration on the behavior of sham-operated rats in the EPM test

From: Psychoimmunological effects of dioscorea in ovariectomized rats: role of anxiety level

  

0 mg/kg/day (n = 11)

250 mg/kg/day (n = 11)

750 mg/kg/day (n = 9)

OAT

Before

40.4 ± 11.5

57.7 ± 11.9

54.4 ± 16.3

 

After

41.5 ± 10.2

58.7 ± 13.0

35.7 ± 9.9

CAT

Before

228.9 ± 16.7

206.0 ± 16.3

211.4 ± 17.4

 

After

221.7 ± 15.0

174.3 ± 25.5

225.8 ± 13.1

OAA

Before

3.9 ± 1.3

7.7 ± 1.7

6.6 ± 2.5

 

After

6.2 ± 1.5

8.2 ± 1.6

6.0 ± 2.1

CAA

Before

20.5 ± 2.6

22.3 ± 3.9

20.7 ± 3.0

 

After

22.6 ± 2.4

18.4 ± 2.6

23.6 ± 1.6

TAA

Before

24.4 ± 3.4

30.0 ± 3.6

27.2 ± 4.0

 

After

28.7 ± 2.6

26.6 ± 3.1

29.6 ± 2.5

  1. OAT, open arm time; CAT, enclosed arm time; OAA, open arm activity; CAA, enclosed arm activity; TAA, total arm activity. The data are expressed as the mean ± SEM. "Before" and "after" are the results for the EPM test before, and on day 23 of, dioscorea treatment.