Table 4 Effect of chronic dioscorea administration on the behavior of OVX rats in the EPM test
From: Psychoimmunological effects of dioscorea in ovariectomized rats: role of anxiety level
| Â | Â | LA rats | HA rats | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Â | Â | 0 mg/kg/day (n = 8) | 250 mg/kg/day (n = 10) | 750 mg/kg/day (n = 9) | 1 500 mg/kg/day (n = 7) | 0 mg/kg/day (n = 7) | 250 mg/kg/day (n = 8) | 750 mg/kg/day (n = 9) | 1 500 mg/kg/day (n = 10) |
OAT | Before | 59.3 ± 8.9 | 50.6 ± 6.5 | 57.5 ± 9.6 | 59.6 ± 14.5 | 5.1 ± 3.6 | 6.0 ± 3.3 | 6.5 ± 3.4 | 3.9 ± 2.7 |
|  | After | 32.3 ± 11.4 | 23.2 ± 7.1 ** | 49.6 ± 9.5 | 37.6 ± 14.2 | 10.8 ± 5.8 | 17.2 ± 6.9 | 33.5 ± 8.4 ** | 21.3 ± 7.2 * |
CAT | Before | 205.5 ± 9.4 | 220.8 ± 8.8 | 209.3 ± 12.5 | 206.6 ± 16.8 | 277.0 ± 11.8 | 269.2 ± 7.5 | 261.8 ± 9.6 | 276.3 ± 5.3 |
|  | After | 228.3 ± 19.4 | 247.0 ± 14.6 | 211.1 ± 15.6 | 224.2 ± 22.4 | 264.2 ± 10.7 | 264.9 ± 10.4 | 239.3 ± 13.9 * | 239.6 ± 12.8 * |
OAA | Before | 8.0 ± 0.8 | 5.2 ± 0.9 | 9.7 ± 2.8 | 8.0 ± 2.8 | 0.6 ± 0.6 | 0.8 ± 0.5 | 0.9 ± 0.9 | 0.4 ± 0.3 |
|  | After | 6.3 ± 1.9 | 2.8 ± 0.9 * | 7.6 ± 1.9 | 5.4 ± 2.3 | 1.1 ± 0.9 | 2.5 ± 1.2 | 3.9 ± 1.3 ** | 1.8 ± 0.7 |
CAA | Before | 21.8 ± 3.4 | 19.5 ± 1.3 | 24.0 ± 2.8 | 21.3 ± 3.4 | 27.1 ± 3.3 | 23.1 ± 3.4 | 28.4 ± 3.4 | 28.5 ± 3.1 |
|  | After | 20.5 ± 3.5 | 22.1 ± 3.0 | 21.3 ± 2.4 | 21.1 ± 3.5 | 20.6 ± 1.9 | 18.1 ± 2.8 | 19.9 ± 2.6 * | 24.9 ± 2.8 |
TAA | Before | 29.8 ± 3.5 | 24.7 ± 1.7 | 33.7 ± 4.2 | 29.3 ± 5.3 | 27.7 ± 3.5 | 23.9 ± 3.5 | 29.3 ± 3.5 | 28.9 ± 3.0 |
|  | After | 26.8 ± 4.0 | 24.9 ± 3.1 | 28.9 ± 3.0 | 26.6 ± 3.5 | 21.7 ± 2.0 | 20.6 ± 2.8 | 23.8 ± 2.5 | 26.7 ± 2.7 |