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Figure 1 | Annals of General Psychiatry

Figure 1

From: Alcohol significantly lowers the seizure threshold in mice when co-administered with bupropion hydrochloride

Figure 1

Dose-response curves of the percentage of convulsing mice following the administration of bupropion HCl alone (closed circles) and the effect of ethanol pretreatment on bupropion HCl-induced seizures (open circles) in the Swiss albino mice. The 50% convulsing dose (CD50) values, the convulsant doses of bupropion HCl required to induce seizures in 50% of mice were 116.72 (CI: 107.95, 126.20) and 89.40 (CI: 64.92, 123.10) mg/kg for the dose-response curves for bupropion alone and ET + bupropion HCl, respectively. Doses of bupropion HCl administered intraperitoneally (IP) were 0 (vehicle or ET + vehicle only), 100, 110, and 120 mg/kg. Ethanol pretreatment was with 2.5 g/kg IP 5 min prior to administration of bupropion HCl. Each data point is the percentage of convulsing mice in n = 10 mice. ET, ethanol + vehicle; S, vehicle (0.9% NaCl).

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