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Table 1 Effect of ethanol pretreatment on bupropion HCI-induced convulsions: intensity of convulsions

From: Alcohol significantly lowers the seizure threshold in mice when co-administered with bupropion hydrochloride

Dose (mg/kg), n =

10 per group

Intensity of convulsions

 

Mild

Moderate

Severe

 

BUP

ET + BUP

BUP

ET + BUP

BUP

ET + BUP

0 (V or ET +V)

0

1

0

1

0

0

100

1

37

1

65

0

7

110

21

10

1

5

0

0

120

19

17

2

4

0

0

  1. n = 10 mice per group for bupropion HCl alone and ethanol + bupropion HCl treatment groups.
  2. BUP, bupropion HCl; ET, ethanol; V, vehicle or 0.9% sodium chloride (NaCl).
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Annals of General Psychiatry

ISSN: 1744-859X