Alcohol significantly lowers the seizure threshold in mice when co-administered with bupropion hydrochloride

Table 2 Effect of ethanol pretreatment on bupropion HCI-induced convulsions: percentage of convulsing mice

Dose (mg/kg), n = 10 per group	No. of convulsing mice		Percentage of convulsing mice
	Bupropion HCl	ET + Bupropion HCl	Bupropion HCl	ET + Bupropion HCl
0 (vehicle or ET+vehicle)	0	1	0%	10%
100	2	7	20%	70%
110	3	7	30%	70%
120	6	7	60%	70%

n = 10 mice per group for bupropion HCl alone and ethanol + bupropion HCl treatment groups.
ET, ethanol; vehicle, 0.9% sodium chloride (NaCl).

ISSN: 1744-859X