Alcohol significantly lowers the seizure threshold in mice when co-administered with bupropion hydrochloride

Table 3 Effect of ethanol pretreatment on bupropion HCI-induced convulsions: mean standard deviation (SD) convulsions per mouse

Dose (mg/kg), n = 10 per group	Total no. of convulsions		Mean (SD) convulsions per mouse
	BUP	ET + BUP	BUP	ET + BUP	p Value
0 (V or ET +V)	0	2	0.00 (0.00)	0.20 (0.63)	0.1027*
100	2	109	0.20 (0.42)	10.90 (7.28)†
110	22	15	2.20 (4.49)	1.50 (1.72)
120	21	21	2.10 (1.97)	2.10 (3.35)

n = 10 mice per group for bupropion HCl alone and ethanol + bupropion HCl treatment groups.
*p Value for overall ethanol-bupropion interaction effect (ethanol effect, overall p = 0.0183; bupropion dose effect, overall p = 0.0007).
†p = 0.0019 for pairwise comparison with corresponding mean value for bupropion alone treatment.
BUP, bupropion HCl; ET, ethanol; SD, standard deviation; V, vehicle or 0.9% sodium chloride (NaCl).

ISSN: 1744-859X