Table 4 Effect of ethanol pretreatment on bupropion HCI-induced convulsions: duration of convulsions
Dose (mg/kg), n = 10 per group | Duration of convulsions | |||||
|---|---|---|---|---|---|---|
No. of short convulsions (0 to 10 s) | No. of medium convulsions (11 to 30 s) | No. of long convulsions (= 31 s) | ||||
BUP | ET + BUP | BUP | ET + BUP | BUP | ET + BUP | |
0 (V or ET +V) | 0 | 1 | 0 | 1 | 0 | 0 |
100 | 1 | 78 | 1 | 17 | 0 | 14 |
110 | 22 | 6 | 0 | 3 | 0 | 6 |
120 | 18 | 17 | 3 | 1 | 0 | 3 |