Table 4 Mean ± SD number of short, medium, and long convulsions following the intraperitoneal administration of bupropion HCl and bupropion metabolites
From: Convulsive liability of bupropion hydrochloride metabolites in Swiss albino mice
Dose* (mg/kg) | Bupropion HCl | Erythrohydrobupropion HCl | Threohydrobupropion HCl | Hydroxybupropion HCl | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|  | Short (0–10 s) | Medium (11–30 s) | Long (≥ 31 s) | Short (0–10 s) | Medium (11–30 s) | Long (≥ 31 s) | Short (0–10 s) | Medium (11–30 s) | Long (≥ 31 s) | Short (0–10 s) | Medium (11–30 s) | Long (≥ 31 s) |
25 | - | - | - | - | - | - | - | - | - | - | - | - |
50 | - | - | - | 0.1 ± 0.3 | - | - | 6.6 ± 8.9 | 0.3 ± 0.5 | 0.1 ± 0.3 | 7.9 ± 8.3 | 1.6 ± 2.6 | 1.5 ± 1.6 |
75 | 0.5 ± 1.6 | - | - | 4.4 ± 6.0 | 0.6 ± 1.0 | 0.5 ± 0.5 | 13.2 ± 9.7 | 5.5 ± 6.6 | 2.5 ± 2.3 | 136.1 ± 108.2 | 8.0 ± 7.2 | 3.4 ± 3.3 |