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Table 1 Effect of bupropion HCl 120 mg/kg intraperitoneal infusion times on bupropion HCl-induced percentage of convulsing mice and on odds of convulsing vs not convulsing

From: Effect of increasing intraperitoneal infusion rates on bupropion hydrochloride-induced seizures in mice

Group* Intraperitoneal (IP) infusion time (min) No. of mice convulsing Convulsing mice Reduction in odds of convulsing†
1 0 (bolus) 6 60% -
2 15 9 90% 32.6%
3 30 5 50% 54.6%
4 60 5 50% 79.4%
5 90 0 0% 90.6%
6 120 2 20% 95.8%
7 240 0 0% 99.8%
  1. *Number of mice was 10 for each group, except group 5 that had 9 mice.
  2. †Reduced odds of convulsing vs not convulsing for any infusion time, x min, were calculated using the formula: 1 - (0.974x) × 100%; where 0.974 was the odds ratio estimate obtained from logistic regression analysis, and x = infusion time (min).