Table 1 Effect of bupropion HCl 120 mg/kg intraperitoneal infusion times on bupropion HCl-induced percentage of convulsing mice and on odds of convulsing vs not convulsing
Group* | Intraperitoneal (IP) infusion time (min) | No. of mice convulsing | Convulsing mice | Reduction in odds of convulsing†|
|---|---|---|---|---|
1 | 0 (bolus) | 6 | 60% | - |
2 | 15 | 9 | 90% | 32.6% |
3 | 30 | 5 | 50% | 54.6% |
4 | 60 | 5 | 50% | 79.4% |
5 | 90 | 0 | 0% | 90.6% |
6 | 120 | 2 | 20% | 95.8% |
7 | 240 | 0 | 0% | 99.8% |