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Table 2 Effect of bupropion HCl 120 mg/kg intraperitoneal infusion times on time to onset of bupropion HCl-induced convulsions and on odds of convulsing vs not convulsing in mice

From: Effect of increasing intraperitoneal infusion rates on bupropion hydrochloride-induced seizures in mice

Group*

Intraperitoneal (IP) infusion time (min)

Time to Onset of Convulsions for Individual Mice (min)†

Reduction in hazard (probability) of convulsing

1

0 (bolus)

7; 30; 6; 120; 5; 11; 120; 120; 23; 120

-

2

15

15; 120; 5; 18; 19; 23; 14; 20; 16; 13

28.4%

3

30

20; 120; 17; 120; 120; 120; 120; 39; 42; 31

48.7%

4

60

32; 120; 42; 120; 120; 60; 120; 70; 120; 69

73.7%

5

90

120; 120; 120; 120; 120; 120; 120; 120; 120

86.5%

6

120

120; 9; 41; 120; 120; 120; 120; 120; 120; 120

93.1%

7

240

120; 120; 120; 120; 120; 120; 120; 120; 120; 120

99.5%

  1. *Number of mice was 10 for each group, except group 5 that had 9 mice.
  2. †Mice that did not have convulsions during treatment infusion and by the end of the 2-h post-treatment period were considered to be censored at 120 min.
  3. ‡Reduced hazard of convulsing vs not convulsing for any infusion time, x min, was calculated using the formula: 1 - (0.978x) × 100%; where 0.978 was the hazard ratio estimate obtained from Cox proportional hazards model, and x = infusion time (min).
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Annals of General Psychiatry

ISSN: 1744-859X