Skip to main content

Table 2 Effect of bupropion HCl 120 mg/kg intraperitoneal infusion times on time to onset of bupropion HCl-induced convulsions and on odds of convulsing vs not convulsing in mice

From: Effect of increasing intraperitoneal infusion rates on bupropion hydrochloride-induced seizures in mice

Group* Intraperitoneal (IP) infusion time (min) Time to Onset of Convulsions for Individual Mice (min)† Reduction in hazard (probability) of convulsing
1 0 (bolus) 7; 30; 6; 120; 5; 11; 120; 120; 23; 120 -
2 15 15; 120; 5; 18; 19; 23; 14; 20; 16; 13 28.4%
3 30 20; 120; 17; 120; 120; 120; 120; 39; 42; 31 48.7%
4 60 32; 120; 42; 120; 120; 60; 120; 70; 120; 69 73.7%
5 90 120; 120; 120; 120; 120; 120; 120; 120; 120 86.5%
6 120 120; 9; 41; 120; 120; 120; 120; 120; 120; 120 93.1%
7 240 120; 120; 120; 120; 120; 120; 120; 120; 120; 120 99.5%
  1. *Number of mice was 10 for each group, except group 5 that had 9 mice.
  2. †Mice that did not have convulsions during treatment infusion and by the end of the 2-h post-treatment period were considered to be censored at 120 min.
  3. ‡Reduced hazard of convulsing vs not convulsing for any infusion time, x min, was calculated using the formula: 1 - (0.978x) × 100%; where 0.978 was the hazard ratio estimate obtained from Cox proportional hazards model, and x = infusion time (min).