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  • Poster presentation
  • Open Access
  • Psychosis in a multiple sclerosis patient and antipsychotic treatment

    • 1,
    • 1,
    • 1 and
    • 2
    Annals of General Psychiatry20087 (Suppl 1) :S254

    • Published:


    • Multiple Sclerosis
    • Interferon
    • Clozapine
    • Risperidone
    • Multiple Sclerosis Patient


    Multiple sclerosis (MS) is a central nervous system demyelinating disease usually diagnosed on the basis of typical neurological symptoms and signs, clinical course, and laboratory and neuroradiological findings. Psychiatric symptoms and disorders frequently co-occur in MS.

    Materials and methods

    We examined the evidence of correlation between relapses of the comorbid psychosis in a multiple sclerosis (MS) patient and progression of the disease. This case report also deals with the antipsychotic treatment and his necessary modifications.


    We present a case of a 35 years old male affected by multiple sclerosis in the last 6 years under treatment with interferons. One year after the diagnosis of the demyelinating disease, the patient developed psychiatric manifestations and he referred to a psychiatric clinic where was formulated the diagnosis of psychosis. There was no family or personal history of psychiatric disease or psychotropic medication/substance use. The patient initially has been treated with risperidone and with an exception of a relapse, because of non-compliance, has been almost stable for about 5 years. At the age of 35 years he has been recovered to our clinic due to a severe exacerbation of the psychosis which persistent symptoms leaded to a change of the antipsychotic treatment. Initially he began on sertindole for one month with poor response. Thus he has changed treatment and the following administration of clozapine had as a result the remission of the symptoms.


    The progression of the MS frequently comports exacerbation of the symptomatology of the comorbid psychosis. Clozapine seems to constitute a valid treatment.



    The authors wish to appreciate the patient for his kind co-operation.

    Open AccessThis article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Authors’ Affiliations

    Department of Psychiatry, Psychiatric Hospital of Tripoli, Tripoli, Greece
    Department of Nephrology, General Hospital of Rhodes, Rhodes, Greece


    1. Claudia Diaz-Olavarrieta, Cummings Jeffrey, Julia Velazquez, de al Cadena Claudia Garcia: Neuropsychiatric manifestations of multiple sclerosis. J Neuropsychiatry Clin Neurosci. 1999, 11: 51-53.View ArticleGoogle Scholar
    2. Lyoo IK, Seol HY, Byun HS: Unsuspected multiple sclerosis in patients with psychiatric disorders: a magnetic resonance imaging study. J Neuropsychiatry Clin Neurosci. 1996, 8: 54-59.View ArticlePubMedGoogle Scholar


    © Georgopoulou et al.; licensee BioMed Central Ltd. 2008

    This article is published under license to BioMed Central Ltd.