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  • Open Access
  • Effects of NMDA receptor blockade in early developmental period on emotional behaviors in adult social isolated rats reared in physical barren and enriched conditions

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    Annals of General Psychiatry20087 (Suppl 1) :S293

    https://doi.org/10.1186/1744-859X-7-S1-S293

    • Published:

    Keywords

    • Social Isolate
    • Exploratory Behavior
    • Enrich Environment
    • Saline Treatment
    • Elevated Plus Maze

    Background

    It is known that N-methyl-D-aspartate (NMDA) type of glutamate receptors in the brain play important roles in the development of neuronal migration, dendritic arborization and establishment of synaptic connections. Forasmuch, cognitive and emotional health is dependent of social and physical variety in rearing period.

    Materials and methods

    The present study is investigate the effects of chronic NMDA receptor blockade in the last maturation period of the brain (between postnatal 10-20 days; 0.25 mg/kg MK-801, twice daily, s.c.) on the anxiety-like behaviors in social isolated (SI) rats that were reared in barren and enriched environments. Anxiety behaviors were evaluated by using an open-field (OF) and elevated plus maze (EPM) test in adulthood.

    Results

    In the (OF), behaviors of the SI rats reared in enriched environment were characterized by increased upward exploratory behavior (P<0.05) and decreased the number of fecal boli ((P<0.05), compared to the SI rats reared in barren environment. Blockade of NMDA receptors in SI barren and enrich reared rats resulted in increased ambulatory locomotion without changing all other OF behaviors, compared to the saline treatment. In the EPM, when reared in enrich environment, SI rats with saline treatment showed decreased anxiety state, expressed as a significant decrease in the time spent in open arms (P<0.05) and an increase in time spent in the close arms (P<0.05) with increases in ethological type of exploratory behaviors (head streached, P<0.05; upward exploratory behavior, P<0.001; and self-grooming P<0.05), compared to the SI rats reared barren environment. NMDA receptor blockade attenuates the effects of physical enrichment in the EPM.

    Conclusions

    These findings indicate that NMDA receptor blockade in the last maturation period of brain development is implicated in forming multiple associations with environment.

    Declarations

    Acknowledgements

    Cukurova University Research Fund no: TF2006D1

    Open AccessThis article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Authors’ Affiliations

    (1)
    Department of physiology, Cukurova University, Seyhan, Adana, Turkey

    Copyright

    © Kocahan et al.; licensee BioMed Central Ltd. 2008

    This article is published under license to BioMed Central Ltd.

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