Neuropsychological association between paranoid schizophrenia and delusional misidentification syndromes: an in between subjects design
© Typaldou et al.; licensee BioMed Central Ltd. 2008
- Published: 17 April 2008
- Cognitive Function
- Frontal Lobe
- Schizophrenic Patient
- Neuropsychological Test
Delusional Misidentification Syndromes (DMSs) have been observed in a variety of psychiatric and other medical conditions but they seem to be strongly associated with schizophrenia since they occur predominantly in the context of paranoid schizophrenia. Previous studies about a neuropsychological relationship between DMSs and schizophrenia have implicated cognitive functions performed by bilateral frontal and right hemisphere in both schizophrenia and DMS, but there are mainly case reports, lacking the appropriate controls. Aim of the present study was to investigate whether DMS in paranoid schizophrenia is mediated by a distinct neuropsychological substrate indicative of differential bilateral frontal and right hemisphere dysfunction.
The sample of the study included 44 right-handed schizophrenic patients, 22 of them with DMSs and 22 without previous history of DMMs, matched for gender, age, education, severity and duration of illness. Both groups were on medication with comparable doses of atypical antipsychotics. The neuropsychological battery used was designed to assess cognitive functions mainly associated with right hemisphere and frontal lobe areas. DMMs were active and their counterparts were also deluded at the time of neuropsychological assessment.
No statistically significant differences were found between the two groups in terms of their mean performance in all neuropsychological tests. Both groups showed evidence of dysfunction in frontal and right cerebral regions.
Our findings show evidence of right hemisphere and frontal lobe dysfunction of equal severity in both groups of paranoid schizophrenic patients with and without DMS and suggest that DMS and paranoid schizophrenia share the same neuropsychological substrate.
- Coltheart M., Langdon R., McKay R.: Schizophrenia and monothematic delusions. Schizophr Bull. 2007, 33: 642-647. 10.1093/schbul/sbm017.PubMed CentralView ArticlePubMedGoogle Scholar
- Coltheart M.: The 33rd Sir Frederick Bartlett Lecture. Cognitive neuropsychiatry and delusional belief. The quarterly Journal of Experimental Psychology. 2007, 60: 1041-1062. 10.1080/17470210701338071.View ArticlePubMedGoogle Scholar
- Cutting J.: Evidence for right hemisphere dysfunction in Schizophrenia. In: The neuropsychology of schizophrenia. Edited by: AS David and JC Cutting. 1994, Lawrence Erlbaum Associates LtdGoogle Scholar
- Edelstyn N.M.J., Oyebode F.: A review of the phenomenology and cognitive neuropsychological origins of the Capgras syndrome. International Journal of Geriatric Psychiatry. 1999, 14: 48-59. 10.1002/(SICI)1099-1166(199901)14:1<48::AID-GPS891>3.0.CO;2-0.View ArticlePubMedGoogle Scholar
- Ellis H.D., de Pauw K.W., Christodoulou G.N., Papageorgiou L., Milne A.B., Joseph A.B.: Responses to facial and nonfacial stimuli presented tachistoscopically in either or both visual fields by patients with the Capgras delusion and paranoid schizophrenics. Journal of Neurology Neurosurgery and Psychiatry. 1993, 56: 215-219.View ArticleGoogle Scholar
- Ellis H.D., Luatι J.P., Rettestrol N.: Delusional Misidentification Syndromes. Psychopathology. 1994, 27: 117-120.View ArticlePubMedGoogle Scholar
- Joseph A.B.: Focal central nervous system abnormalities in patients with misidentification syndromes. Bibliotheca Psychiatrica. 1986, 164: 68-79.PubMedGoogle Scholar
- Kokkevi A., Christodoulou G.N.: Psychometric Investigation of patients with Delusional Misidentification Syndromes. Psychiatry the State of Art. Edited by: P. Pichot, P. Berner, R. Wolf & K. Thau. 1985, Plenum Press, 841-849.Google Scholar
- Lezak M.D.: Neuropsychological Assessment. 2004, Oxford University Press, Inc, 4rd ednGoogle Scholar
- Lykouras L., Typaldou M., Gournellis R., Vaslamatzis G., Christodoulou G.N.: Coexistence of Capgras and Frιgoli syndromes in a single patient. Clinical, neuroimaging and neuropsychological findings, European Psychiatry. 2002, 17: 234-235.PubMedGoogle Scholar
- Morrison R.L., Tarter R.E.: Neuropsychological Findings Relating to Capgras Syndrome. Biological Psychiatry. 1984, 19: 1119-1128.PubMedGoogle Scholar
- Paillιre-Martinot M.L., Dao-Castellana M.H., Masure M. C., Pillon B., Martinot J.L.: Delusional Misidentification: A Clinical Neuropsychological and Brain Imaging Case Study. Psychopathology. 1994, 27: 200-210.View ArticleGoogle Scholar
- Wilcox J., Waziri R.: The Capgras symptom and nondominant cerebral dysfunction. Journal of Clinical Psychiatry. 1983, 44: 70-72.PubMedGoogle Scholar
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