Skip to main content

Table 1 Pathophysiological models of schizophrenia and their associated drugs

From: Schizophrenia pathophysiology: are we any closer to a complete model?

Models Relevant drugs References
Development of brain changes due to prenatal or perinatal insult(s); neurodevelopment hypothesis   [14, 8]
Due to disruption of working memory leading to reduced working memory even with normal brain function   [1015]
Genetic inheritance contributes to the onset of schizophrenia   [18, 19]
Decomposition of the oligodendrocyte-axonic system causes symptoms of schizophrenia; oligodendrocytic computation capacity theory   [17]
The NPY gene is a susceptibility gene for schizophrenia; reduction of levels of neuropeptide Y (NPY) in the brain leads to pathological changes   [26, 27, 29]
Reduced expression of DTNBP1 confers susceptibility to schizophrenia   [21, 22]
PRODH is deleted in schizophrenia patients and may play a significant role in the pathophysiology of schizophrenia.   [23]
DAOA (G72) produces a gene product that affects glutamate signaling in schizophrenia patients   [24]
TAAR6 is a familial gene that is constitutively expressed in the brain and was discovered in families who had a history of schizophrenia   [23]
Expression changes or splice variants of ZDHHC8 gene leads to the disruption of excitatory synaptic transmission in the brain and increases the risk of developing schizophrenia   [25]
Multiple single nucleotide polymorphisms (SNPs) of NRG1 appear to cause speech deficits on the semantic level and might increase the susceptibility to schizophrenia   [26, 27]
Increased levels of COMT are associated with glial abnormalities and altered dopamine-glutamate interactions   [28, 29]
Decreased levels of DISC1 cause neuronal abnormalities that might play a role in schizophrenia pathogenesis   [30, 31]
Due to alterations in glutamatergic N-methyl-D-aspartate (NMDA) neurotransmission Phencyclidine (PCP) drugs [40]
Dopamine D2 receptor expression is also highly implicated in the disturbance associated with schizophrenia Aripiprazole, haloperidol [37, 42]
Phosphatidylinositol-4-phosphate 5-kinase (PI4,5K) has been strongly associated in the incidence of schizophrenia Sildenafil [41]