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Table 3 Adverse drug event reports linking isotretinoin and psychiatric side effects

From: Isotretinoin and psychopathology: a review

Reference Year No. of patients Psychiatric adverse effect
US Food and Drug Administration [25] 1982 to 2004 4,992 Various psychiatric side effects: 192 suicide attempts
Canada [26] 1983 to 2003 56 Depression
UK [27] 1982 to 2006 463 Suspected psychiatric events: 25 completed suicides
Australia [28] 1985 to 1988 12 Depression: Suicide attempts (2)