Treatment of psychotic symptoms in bipolar disorder with aripiprazole monotherapy: a meta-analysis

Table 1 List of acute mania trials of aripiprazole and their characteristics

Trial	Publication	Duration	COMP	PLC	Randomised, N			Efficacy sample, N			Safety sample, N			Results
					AR	COMP	PLC	AR	COMP	PLC	AR	COMP	PLC
CN138-009	Keck et al., 2003 [27]	3 weeks	No	Yes									127	Agent > PLC
CN138-074/NCT00036101	Sachs et al., 2006 [28]	3 weeks	No	Yes	137		135	136		132	136		133	Agent > PLC
CN138-135/NCT00095511	Keck et al., 2009 [29]	12 weeks	Li	Yes	155	160	165	154	155	163	154	159	164	Agent = comparator > PLC
CN138-162/NCT00097266	Young et al., 2009 [30]	12 weeks	Hal	Yes	167	165	153	152	161	152	166	165	153	Agent = comparator > PLC
CN138-007	Unpublished	3 weeks	No	Yes	267		134	267 -		134 -	267 -		134 -	Agent = PLC
CN138-077/NCT00046384	Unpublished	3 weeks	No	Yes	29		27							No results
CN138008	Vieta et al., 2005 [32]	12 weeks	Hal	No	175	172		171	158		175	169		Agent > comparator
All RCTs
Total by groups					1,060	497	746	1,005	474	704	1,025	493	711
Total							2,303			2,183			2,229
Only RCTs with PANSS data
Total by groups					663	497	480	613	474	447	631	493	450
Total							1,640			1,534			1,574

Dash indicates missing data. AR = aripiprazole; COMP = comparator; PANSS = Positive and Negative Syndrome Scale; PLC = placebo; RCT = randomised controlled trial.

ISSN: 1744-859X