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Table 4 Change in Positive and Negative Syndrome Scale (PANSS) scores in acute mania aripiprazole randomised controlled trials (RCTs)

From: Treatment of psychotic symptoms in bipolar disorder with aripiprazole monotherapy: a meta-analysis

Trial

3 weeks

12 weeks

N (efficacy sample)

 

PANSS-total

PANSS-positive

PANSS-negative

PANSS-cognitive

PANSS-hostility

PANSS-total

PANSS-positive

PANSS-negative

PANSS-cognitive

PANSS-hostility

 

Aripiprazole

 

CN138-009

-

-

-

-

-

     

125

CN138-074

-10.0 ± 18.2

-

-

-

-

     

136

CN138-135

-9.5 ± 17.4

-

-

-2.0 ± 4.6

-2.1 ± 4.6

-10.6 ± 19.4

-

-

-2.9 ± 5.7

-2.5 ± 4.6

154

CN138-162

-8.2 ± 12.9

-3.8 ± 5.1

-0.4 ± 2.6

-2.4 ± 3.9

-2.3 ± 3.9

-9.8 ± 14.2

-4.9 ± 5.2

-0.2 ± 2.6

-3.2 ± 5.2

-3.0 ± 3.9

152

CN138-007

-2 ± -a

-

-

-

-

     

267 -

CN138-008

-

-

-

-

-

-

-

-

-

-

171

Pooled mean

-6.5

-3.8

-0.4

-2.2

-2.2

-10.2

-4.9

-0.2

-3.0

-2.7

1,005

Pooled SD

16.3

5.1

2.6

4.3

4.3

16.9

5.2

2.6

5.5

4.3

 

Placebo

 

CN138-009

-

-

-

-

-

     

123

CN138-074

-5.3 ± 17.9

-

-

-

-

     

132

CN138-135

-4.9 ± 16.7

-

-

-0.9 ± 4.8

-1.0 ± 3.6

     

163

CN138-162

-4.7 ± 12.4

-2.4 ± 4.9

-0.1 ± 2.5

-1.5 ± 6.2

-1.2 ± 6.2

     

152

CN138-007

-2.3 ± -a

-

-

-

-

     

134 -

CN138-008

           

Pooled mean

-4.3

-2.4

-0.1

-1.2

-1.1

     

704

Pooled SD

15.8

4.9

2.5

5.5

5.0

      

Comparator

 

CN138-009

           

CN138-074

           

CN138-135

-7 ± 17.7

-

-

-1.6 ± 4.7

-1.6 ± 3.5

-7.4 ± 18.8

-

-

-2.0 ± 4.7

-1.8 ± 4.7

155

CN138-162

-8.8 ± 12.8

-4.2 ± 5.1

-0.3 ± 2.6

-2.5 ± 3.9

-2.6 ± 3.9

-11.7 ± 14.1

-5.4 ± 5.1

-0.3 ± 2.6

-3.9 ± 5.1

-3.5 ± 3.9

161

CN138-007

           

CN138-008

-

-

-

-

-

-

-

-

-

-

158

Pooled mean

-7.9

-4.2

-0.3

-2.0

-2.1

-9.6

-5.4

-0.3

-3

-2.7

474

Pooled SD

15.4

5.1

2.6

4.3

3.7

16.6

5.1

2.6

4.9

4.3

 
  1. Dash indicates missing data.
  2. aNot included in the calculation of the pooled measures because of a different study design (fixed dosage).