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Table 2 Pharmacokinetic parameters of loxapine

From: Revisiting loxapine: a systematic review

pKa

6.6

Half-life

 

Route oral

4 h (range 1–14)

Intramuscular

12 h (range 8–23)

Inhalatory route

4 h (range 6–8)

Time to peak concentration

 

Route oral

1 h

Intramuscular

5 h

Inhalatory route

2 min (1–3)

Metabolites

7- and 8-Hydroxyloxapine

Desmethyl-loxapine (amoxapine)

7- and 8-Hydroxyamoxapine

 

Ioxapine N-oxide

Excretion

Excretion of glucuronide conjugates in urine

Unchanged in faeces